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    Hdac6 histone deacetylase 6 [ Mus musculus (house mouse) ]

    Gene ID: 15185, updated on 12-Sep-2021

    Summary

    Official Symbol
    Hdac6provided by MGI
    Official Full Name
    histone deacetylase 6provided by MGI
    Primary source
    MGI:MGI:1333752
    See related
    Ensembl:ENSMUSG00000031161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hd6; Sfc; Sfc6; mHDA; Hdac5; mHDA2
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 65.5), whole brain E14.5 (RPKM 26.3) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hdac6 in Genome Data Viewer
    Location:
    X A1.1; X 3.58 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7796355..7814284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7930116..7948047, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7507248..7525015, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene ES cell-expressed Ras Neighboring gene predicted gene, 39488 Neighboring gene proteasome (prosome, macropain) subunit, beta type 6, pseudogene Neighboring gene GATA binding protein 1 Neighboring gene predicted gene, 52419

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tau protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tubulin deacetylase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables tubulin deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables tubulin deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Hsp90 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aggresome assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aggresome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to topologically incorrect protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyubiquitinated misfolded protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitophagy in response to mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein-containing complex disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
     
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within tubulin deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    histone deacetylase 6
    Names
    histone deacetylase 5
    histone deacetylase mHDA2
    scurfy candidate 6
    tubulin-lysine deacetylase HDAC6
    NP_001123888.1
    NP_034543.3
    XP_006527630.1
    XP_017173878.1
    XP_036017717.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130416.1NP_001123888.1  histone deacetylase 6

      See identical proteins and their annotated locations for NP_001123888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK148092, BM250542, BY195054, BY234769
      Consensus CDS
      CCDS40845.1
      UniProtKB/Swiss-Prot
      Q9Z2V5
      Related
      ENSMUSP00000111306.2, ENSMUST00000115642.8
      Conserved Domains (3) summary
      cd10003
      Location:484834
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:10671129
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:98434
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. NM_010413.3NP_034543.3  histone deacetylase 6

      See identical proteins and their annotated locations for NP_034543.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF006603, AK148144, BM250542, BY195054, BY234769
      Consensus CDS
      CCDS40845.1
      UniProtKB/Swiss-Prot
      Q9Z2V5
      UniProtKB/TrEMBL
      Q3UG37
      Related
      ENSMUSP00000033501.9, ENSMUST00000033501.15
      Conserved Domains (3) summary
      cd10003
      Location:484834
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:10671129
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:98434
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7796355..7814284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318389.3XP_017173878.1  histone deacetylase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2V5
      Conserved Domains (3) summary
      cd10003
      Location:484834
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:10671129
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:98434
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. XM_036161824.1XP_036017717.1  histone deacetylase 6 isoform X1

      Conserved Domains (3) summary
      cd10003
      Location:484834
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:10671129
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:98434
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    3. XM_006527567.2XP_006527630.1  histone deacetylase 6 isoform X1

      See identical proteins and their annotated locations for XP_006527630.1

      UniProtKB/Swiss-Prot
      Q9Z2V5
      Conserved Domains (3) summary
      cd10003
      Location:484834
      HDAC6-dom2; Histone deacetylase 6, domain 2
      pfam02148
      Location:10671129
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl17011
      Location:98434
      Arginase_HDAC; Arginase-like and histone-like hydrolases
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