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    Hcfc1 host cell factor C1 [ Mus musculus (house mouse) ]

    Gene ID: 15161, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hcfc1provided by MGI
    Official Full Name
    host cell factor C1provided by MGI
    Primary source
    MGI:MGI:105942
    See related
    Ensembl:ENSMUSG00000031386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCF; HCF1; AW060991
    Summary
    This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in thymus adult (RPKM 54.5), adrenal adult (RPKM 25.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hcfc1 in Genome Data Viewer
    Location:
    X A7.3; X 37.52 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (73942792..73967135, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71188134..71211654, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein Neighboring gene predicted gene 8545 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K16 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K5 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K8 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    release from viral latency IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex ISO
    Inferred from Sequence Orthology
    more info
     
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with SAGA-type complex ISO
    Inferred from Sequence Orthology
    more info
     
    Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    host cell factor 1
    Names
    VP16 accessory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008224.4NP_032250.2  host cell factor 1 precursor

      See identical proteins and their annotated locations for NP_032250.2

      Status: REVIEWED

      Source sequence(s)
      AL672002
      Consensus CDS
      CCDS30218.1
      UniProtKB/Swiss-Prot
      Q61191
      Related
      ENSMUSP00000033761.6, ENSMUST00000033761.12
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:18661895
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      73942792..73967135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318387.1XP_017173876.1  host cell factor 1 isoform X3

    2. XM_006527836.1XP_006527899.1  host cell factor 1 isoform X2

      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:19101939
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif
    3. XM_006527835.1XP_006527898.1  host cell factor 1 isoform X1

      UniProtKB/TrEMBL
      B1AUX2
      Related
      ENSMUSP00000110012.2, ENSMUST00000114372.2
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:19111940
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif
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