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    Hccs holocytochrome c synthetase [ Mus musculus (house mouse) ]

    Gene ID: 15159, updated on 5-Sep-2021

    Summary

    Official Symbol
    Hccsprovided by MGI
    Official Full Name
    holocytochrome c synthetaseprovided by MGI
    Primary source
    MGI:MGI:106911
    See related
    Ensembl:ENSMUSG00000031352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in heart adult (RPKM 10.4), limb E14.5 (RPKM 6.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hccs in Genome Data Viewer
    Location:
    X; X F5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168094526..168103370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (169311530..169320374, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (165749462..165758275, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MSL complex subunit 3 Neighboring gene Rho GTPase activating protein 6 Neighboring gene amelogenin, X-linked Neighboring gene predicted gene 15246 Neighboring gene predicted gene 15245

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables holocytochrome-c synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytochrome c-heme linkage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytochrome c-heme linkage ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    holocytochrome c-type synthase; cytochrome c-type heme lyase
    Names
    CCHL
    NP_001317978.1
    NP_001317979.1
    NP_032248.3
    XP_006528768.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331049.1NP_001317978.1  holocytochrome c-type synthase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK028608, BC061466, BM941073
      Consensus CDS
      CCDS30535.1
      UniProtKB/Swiss-Prot
      P53702
      Related
      ENSMUSP00000107743.2, ENSMUST00000112115.2
      Conserved Domains (1) summary
      pfam01265
      Location:5270
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    2. NM_001331050.1NP_001317979.1  holocytochrome c-type synthase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK028608, BC061466, BM941073
      Consensus CDS
      CCDS30535.1
      UniProtKB/Swiss-Prot
      P53702
      Conserved Domains (1) summary
      pfam01265
      Location:5270
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    3. NM_008222.5NP_032248.3  holocytochrome c-type synthase

      See identical proteins and their annotated locations for NP_032248.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK028608, AK077566, BC061466, BM941073
      Consensus CDS
      CCDS30535.1
      UniProtKB/Swiss-Prot
      P53702
      UniProtKB/TrEMBL
      Q8BP79
      Related
      ENSMUSP00000033717.3, ENSMUST00000033717.9
      Conserved Domains (1) summary
      pfam01265
      Location:5270
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      168094526..168103370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528705.2XP_006528768.1  cytochrome c-type heme lyase isoform X1

      See identical proteins and their annotated locations for XP_006528768.1

      UniProtKB/Swiss-Prot
      P53702
      Conserved Domains (1) summary
      pfam01265
      Location:5270
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
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