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    ADRA2B adrenoceptor alpha 2B [ Homo sapiens (human) ]

    Gene ID: 151, updated on 11-Apr-2024

    Summary

    Official Symbol
    ADRA2Bprovided by HGNC
    Official Full Name
    adrenoceptor alpha 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:282
    See related
    Ensembl:ENSG00000274286 MIM:104260; AllianceGenome:HGNC:282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
    Summary
    This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
    Orthologs
    NEW
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    Genomic context

    See ADRA2B in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96112876..96116571, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (96619491..96623187, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96778624..96782310, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene uncharacterized LOC105373494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96725007-96725917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96757989-96758504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96774519-96775506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96798301-96798801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96800355-96800854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16189 Neighboring gene astacin like metalloendopeptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96810561-96811062 Neighboring gene dual specificity phosphatase 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables epinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epinephrine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epinephrine secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of norepinephrine secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of norepinephrine secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor transactivation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    alpha-2B adrenergic receptor
    Names
    ADRA2B adrenergic, alpha-2B-, receptor
    G-protein coupled receptor
    alpha-2 adrenergic receptor subtype C2
    alpha-2-adrenergic receptor-like 1
    alpha-2B adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032950.1 RefSeqGene

      Range
      4579..8274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000682.7NP_000673.2  alpha-2B adrenergic receptor

      See identical proteins and their annotated locations for NP_000673.2

      Status: REVIEWED

      Source sequence(s)
      AC092603, BC133021
      Consensus CDS
      CCDS56129.1
      UniProtKB/Swiss-Prot
      A2RUS0, P18089, Q4TUH9, Q53RF2, Q9BZK0
      Related
      ENSP00000480573.1, ENST00000620793.2
      Conserved Domains (1) summary
      cd15321
      Location:7437
      7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      96112876..96116571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      96619491..96623187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)