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    Slc39a7 solute carrier family 39 (zinc transporter), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 14977, updated on 26-Sep-2022

    Summary

    Official Symbol
    Slc39a7provided by MGI
    Official Full Name
    solute carrier family 39 (zinc transporter), member 7provided by MGI
    Primary source
    MGI:MGI:95909
    See related
    Ensembl:ENSMUSG00000024327 AllianceGenome:MGI:95909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ke4; Ke-4; Zip7; Ring5; H-2Ke4; H2-Ke4
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in cellular zinc ion homeostasis and zinc ion transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in endoplasmic reticulum and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 99.5), adrenal adult (RPKM 66.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc39a7 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34247240..34250664, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34028266..34031690, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 219a-1 Neighboring gene microRNA 219c Neighboring gene H2-K region expressed gene 6 Neighboring gene retinoid X receptor beta Neighboring gene collagen, type XI, alpha 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: H2-Ke6

    Homology

    Clone Names

    • MGC143814, MGC143815

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc transporter SLC39A7
    Names
    H2-K region expressed gene 4
    histidine-rich membrane protein Ke4
    solute carrier family 39 member 7
    zrt-, Irt-like protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077709.1NP_001071177.1  zinc transporter SLC39A7 precursor

      See identical proteins and their annotated locations for NP_001071177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA170090, AK159968, AK167344, BY288782
      Consensus CDS
      CCDS37576.1
      UniProtKB/Swiss-Prot
      Q31125, Q9Z1W1
      UniProtKB/TrEMBL
      A0A068BIT0
      Related
      ENSMUSP00000130102.2, ENSMUST00000169397.9
      Conserved Domains (1) summary
      pfam02535
      Location:140453
      Zip; ZIP Zinc transporter
    2. NM_008202.2NP_032228.2  zinc transporter SLC39A7 precursor

      See identical proteins and their annotated locations for NP_032228.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA170090, AK159968, AK167344, BY288782
      Consensus CDS
      CCDS37576.1
      UniProtKB/Swiss-Prot
      Q31125, Q9Z1W1
      UniProtKB/TrEMBL
      A0A068BIT0
      Related
      ENSMUSP00000025186.9, ENSMUST00000025186.16
      Conserved Domains (1) summary
      pfam02535
      Location:140453
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34247240..34250664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)