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    Pfdn6 prefoldin subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 14976, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pfdn6provided by MGI
    Official Full Name
    prefoldin subunit 6provided by MGI
    Primary source
    MGI:MGI:95908
    See related
    Ensembl:ENSMUSG00000024309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ke-2; H-2Ke2; H2-Ke2
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 40.0), liver E14 (RPKM 35.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Pfdn6 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34157883..34159317, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33938909..33940343, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34075854..34077288, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene ral guanine nucleotide dissociation stimulator-like 2 Neighboring gene WD repeat domain 46 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prefoldin subunit 6
    Names
    H2-K region expressed gene 2
    protein Ke2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185182.1NP_001172111.1  prefoldin subunit 6

      See identical proteins and their annotated locations for NP_001172111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA023721, AV446044, CR974462
      Consensus CDS
      CCDS28636.1
      UniProtKB/Swiss-Prot
      Q03958
      UniProtKB/TrEMBL
      Q792E4
      Related
      ENSMUSP00000137072.2, ENSMUST00000179418.9
      Conserved Domains (1) summary
      cd00632
      Location:9113
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...
    2. NM_010385.2NP_034515.1  prefoldin subunit 6

      See identical proteins and their annotated locations for NP_034515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK010679, AV446044, BY238879
      Consensus CDS
      CCDS28636.1
      UniProtKB/Swiss-Prot
      Q03958
      UniProtKB/TrEMBL
      Q792E4
      Related
      ENSMUSP00000025163.8, ENSMUST00000025163.14
      Conserved Domains (1) summary
      cd00632
      Location:9113
      Prefoldin_beta; Prefoldin beta; Prefoldin is a hexameric molecular chaperone complex, composed of two evolutionarily related subunits (alpha and beta), which are found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34157883..34159317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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