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    H1f0 H1.0 linker histone [ Mus musculus (house mouse) ]

    Gene ID: 14958, updated on 5-Sep-2021

    Summary

    Official Symbol
    H1f0provided by MGI
    Official Full Name
    H1.0 linker histoneprovided by MGI
    Primary source
    MGI:MGI:95893
    See related
    Ensembl:ENSMUSG00000096210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H1f; H1-0; H1fv; H1(0); D130017D06Rik
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
    Orthologs
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    Genomic context

    See H1f0 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78912412..78914704)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79028212..79030504)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78858642..78860934)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene TRIO and F-actin binding protein Neighboring gene predicted gene 10865 Neighboring gene microRNA 6956 Neighboring gene predicted gene, 17753 Neighboring gene glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) Neighboring gene galanin receptor 3 Neighboring gene predicted gene 3924

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC19309, MGC98218, MGC117919

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables minor groove of adenine-thymine-rich DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleosome positioning IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H1.0
    Names
    H1 histone family, member 0
    H1-0 histone
    histone H1'
    histone H1(0)
    myD196

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008197.3NP_032223.2  histone H1.0

      See identical proteins and their annotated locations for NP_032223.2

      Status: REVIEWED

      Source sequence(s)
      AI849476, AK051213, BB661016
      Consensus CDS
      CCDS56990.1
      UniProtKB/Swiss-Prot
      P10922
      Related
      ENSMUSP00000137309.2, ENSMUST00000180086.3
      Conserved Domains (1) summary
      pfam00538
      Location:2596
      Linker_histone; linker histone H1 and H5 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78912412..78914704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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