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    H13 histocompatibility 13 [ Mus musculus (house mouse) ]

    Gene ID: 14950, updated on 22-Aug-2021

    Summary

    Official Symbol
    H13provided by MGI
    Official Full Name
    histocompatibility 13provided by MGI
    Primary source
    MGI:MGI:95886
    See related
    Ensembl:ENSMUSG00000019188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spp; H-13; Hm13; PSL3; AV020344; 1200006O09Rik; 4930443L17Rik; 5031424B04Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 32.1), ovary adult (RPKM 28.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See H13 in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152511292..152550588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152669422..152708668)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (152495197..152534404)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030C14 gene Neighboring gene predicted gene, 31791 Neighboring gene malignant T cell amplified sequence 2 Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
     
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    minor histocompatibility antigen H13
    Names
    presenilin-like aspartyl protease
    presenilin-like protein 3
    signal peptide peptidase beta
    NP_001153023.1
    NP_001153024.1
    NP_001153025.1
    NP_034506.1
    XP_006498846.1
    XP_017171155.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159551.1NP_001153023.1  minor histocompatibility antigen H13 isoform 1

      See identical proteins and their annotated locations for NP_001153023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL845162, CA321999, DQ168449
      Consensus CDS
      CCDS50752.1
      UniProtKB/Swiss-Prot
      Q9D8V0
      Related
      ENSMUSP00000086460.3, ENSMUST00000089059.9
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase
    2. NM_001159552.1NP_001153024.1  minor histocompatibility antigen H13 isoform 3

      See identical proteins and their annotated locations for NP_001153024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL845162, BC056977, CA321999
      Consensus CDS
      CCDS50753.1
      UniProtKB/TrEMBL
      Q6PGJ8
      Related
      ENSMUSP00000105450.2, ENSMUST00000109825.8
      Conserved Domains (1) summary
      cl01342
      Location:62145
      Peptidase_A22B; Signal peptide peptidase
    3. NM_001159553.1NP_001153025.1  minor histocompatibility antigen H13 isoform 4

      See identical proteins and their annotated locations for NP_001153025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK004690, AK013891, CA321999
      UniProtKB/Swiss-Prot
      Q9D8V0
      Conserved Domains (1) summary
      cl01342
      Location:62123
      Peptidase_A22B; Signal peptide peptidase
    4. NM_010376.4NP_034506.1  minor histocompatibility antigen H13 isoform 2

      See identical proteins and their annotated locations for NP_034506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK007664, AL845162, CA321999
      Consensus CDS
      CCDS16896.1
      UniProtKB/Swiss-Prot
      Q9D8V0
      Related
      ENSMUSP00000120068.2, ENSMUST00000125366.8
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152511292..152550588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498783.5XP_006498846.1  minor histocompatibility antigen H13 isoform X2

      Related
      ENSMUSP00000078236.4, ENSMUST00000079247.4
      Conserved Domains (1) summary
      pfam04258
      Location:62350
      Peptidase_A22B; Signal peptide peptidase
    2. XM_017315666.3XP_017171155.1  minor histocompatibility antigen H13 isoform X1

      Conserved Domains (1) summary
      cl01342
      Location:50157
      Peptidase_A22B; Signal peptide peptidase

    RNA

    1. XR_001780858.3 RNA Sequence

    2. XR_374416.3 RNA Sequence

    3. XR_003950808.2 RNA Sequence

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