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    Gk glycerol kinase [ Mus musculus (house mouse) ]

    Gene ID: 14933, updated on 9-Sep-2018

    Summary

    Official Symbol
    Gkprovided by MGI
    Official Full Name
    glycerol kinaseprovided by MGI
    Primary source
    MGI:MGI:106594
    See related
    Ensembl:ENSMUSG00000025059 Vega:OTTMUSG00000017916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gyk; D930012N15Rik
    Expression
    Broad expression in kidney adult (RPKM 16.2), liver E18 (RPKM 11.4) and 17 other tissues See more
    Orthologs

    Genomic context

    Location:
    X C1; X 39.32 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (85701937..85776819, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (82947276..83022158, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene ferritin, heavy polypeptide-like 17, member A Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 3 Neighboring gene predicted gene, 39523 Neighboring gene RIKEN cDNA 5430427O19 gene Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene mitochondrial import receptor subunit TOM20 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycerol kinase
    Names
    ATP:glycerol 3-phosphotransferase
    glycerokinase
    NP_001281067.1
    NP_001281069.1
    NP_032220.1
    NP_997609.1
    XP_006527892.1
    XP_006527894.1
    XP_006527896.1
    XP_017173875.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294138.1NP_001281067.1  glycerol kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains one alternate exon and lacks two alternate exons in the coding region, but maintains the reading frame, compared to variant 4. The encoded isoform (3) is shorter than isoform 4.
      Source sequence(s)
      AK169424, AK169525, AL645567, BQ176629
      Consensus CDS
      CCDS81150.1
      UniProtKB/TrEMBL
      B1ASZ3, Q3TEN9, Q3TET2
      Related
      ENSMUSP00000120754.1, OTTMUSP00000019467, ENSMUST00000142152.1, OTTMUST00000043305
      Conserved Domains (2) summary
      cd07792
      Location:11541
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11541
      glycerol_kin; glycerol kinase
    2. NM_001294140.1NP_001281069.1  glycerol kinase isoform 4

      See identical proteins and their annotated locations for NP_001281069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AK044308, AK169424, AK169525, AL645567, AL672056, BQ176629
      Consensus CDS
      CCDS81149.1
      UniProtKB/Swiss-Prot
      Q64516
      UniProtKB/TrEMBL
      Q3TEN9, Q3TET2
      Related
      ENSMUSP00000109611.2, OTTMUSP00000019465, ENSMUST00000113978.8, OTTMUST00000043303
      Conserved Domains (2) summary
      cd07792
      Location:11519
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11519
      glycerol_kin; glycerol kinase
    3. NM_001331046.1NP_001317975.1  glycerol kinase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 4. The encoded isoform (5) is shorter than isoform 4.
      Source sequence(s)
      AK169424, AK169525, BQ176629, CF535556
      UniProtKB/TrEMBL
      Q3TEN9, Q3TET2
    4. NM_008194.3NP_032220.1  glycerol kinase isoform 1

      See identical proteins and their annotated locations for NP_032220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks two alternate in-frame exons in the coding region compared to variant 4. The encoded isoform (1) is shorter than isoform 4.
      Source sequence(s)
      AK169424, AK169525, AL672056, BQ176629
      Consensus CDS
      CCDS53126.1
      UniProtKB/Swiss-Prot
      Q64516
      UniProtKB/TrEMBL
      Q3TEN9, Q3TET2
      Related
      ENSMUSP00000026039.8, OTTMUSP00000019464, ENSMUST00000026039.14, OTTMUST00000043302
      Conserved Domains (2) summary
      cd07792
      Location:11513
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11513
      glycerol_kin; glycerol kinase
    5. NM_212444.2NP_997609.1  glycerol kinase isoform 2

      See identical proteins and their annotated locations for NP_997609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 4. The encoded isoform (2) is shorter than isoform 4.
      Source sequence(s)
      AL645567, AL672056
      Consensus CDS
      CCDS41050.1
      UniProtKB/Swiss-Prot
      Q64516
      Related
      ENSMUSP00000119564.1, OTTMUSP00000019466, ENSMUST00000156390.7, OTTMUST00000043304
      Conserved Domains (2) summary
      cd07792
      Location:11513
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11513
      glycerol_kin; glycerol kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      85701937..85776819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318386.1XP_017173875.1  glycerol kinase isoform X4

    2. XM_006527831.3XP_006527894.1  glycerol kinase isoform X2

      Conserved Domains (2) summary
      cd07792
      Location:11541
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11541
      glycerol_kin; glycerol kinase
    3. XM_006527833.3XP_006527896.1  glycerol kinase isoform X3

      Conserved Domains (2) summary
      cd07792
      Location:11547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11547
      glycerol_kin; glycerol kinase
    4. XM_006527829.3XP_006527892.1  glycerol kinase isoform X1

      Conserved Domains (2) summary
      cd07792
      Location:11547
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:11547
      glycerol_kin; glycerol kinase
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