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    NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 149281, updated on 5-Mar-2024

    Summary

    Official Symbol
    NTMT2provided by HGNC
    Official Full Name
    N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:31932
    See related
    Ensembl:ENSG00000203740 AllianceGenome:HGNC:31932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTM1B; HOMT1B; C1orf184; METTL11B
    Summary
    Enables N-terminal protein N-methyltransferase activity. Involved in N-terminal protein amino acid methylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See NTMT2 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (170145959..170168866)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169501867..169524770)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (170115100..170138007)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin associated protein 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:169972353-169972990 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1549 Neighboring gene sialic acid binding Ig like lectin 30, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170114681-170115212 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:170115213-170115743 Neighboring gene microRNA 3119-1 Neighboring gene microRNA 3119-2 Neighboring gene long intergenic non-protein coding RNA 1681 Neighboring gene iron-sulfur cluster assembly enzyme pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1142

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    EBI GWAS Catalog

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-terminal protein N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in N-terminal protein amino acid methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    N-terminal Xaa-Pro-Lys N-methyltransferase 2
    Names
    X-Pro-Lys N-terminal protein methyltransferase 1B
    alpha N-terminal protein methyltransferase 1B
    methyltransferase like 11B
    methyltransferase-like protein 11B
    NP_001129579.1
    XP_011507534.1
    XP_011507535.1
    XP_011507536.1
    XP_054190616.1
    XP_054190617.1
    XP_054190618.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136107.2NP_001129579.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2

      See identical proteins and their annotated locations for NP_001129579.1

      Status: VALIDATED

      Source sequence(s)
      AL445203
      Consensus CDS
      CCDS44275.1
      UniProtKB/Swiss-Prot
      B2RXI0, Q5VVY1
      Related
      ENSP00000408058.3, ENST00000439373.3
      Conserved Domains (1) summary
      cl17173
      Location:67277
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      170145959..170168866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509233.3XP_011507535.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011507535.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_011509232.3XP_011507534.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011507534.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_011509234.3XP_011507536.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011507536.1

      Conserved Domains (1) summary
      cl17173
      Location:2212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169501867..169524770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334641.1XP_054190616.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    2. XM_054334642.1XP_054190617.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    3. XM_054334643.1XP_054190618.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1