U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CNIH3 cornichon family AMPA receptor auxiliary protein 3 [ Homo sapiens (human) ]

    Gene ID: 149111, updated on 2-May-2024

    Summary

    Official Symbol
    CNIH3provided by HGNC
    Official Full Name
    cornichon family AMPA receptor auxiliary protein 3provided by HGNC
    Primary source
    HGNC:HGNC:26802
    See related
    Ensembl:ENSG00000143786 AllianceGenome:HGNC:26802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNIH-3
    Summary
    Predicted to enable channel regulator activity. Involved in regulation of AMPA receptor activity. Predicted to be located in dendritic shaft and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in dendrite and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 4.8), testis (RPKM 1.6) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CNIH3 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (224434640..224740554)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (223623489..223929352)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (224622342..224928256)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:224544931-224545431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2611 Neighboring gene cornichon family member 4 Neighboring gene WD repeat domain 26 Neighboring gene microRNA 4742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:224616083-224616672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:224616673-224617262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2612 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:224661692-224661861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:224667779-224668305 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:224685507-224686036 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:224686037-224686568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:224687944-224688444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:224688445-224688945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:224696756-224697667 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:224703315-224703519 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:224759465-224759964 Neighboring gene aldehyde reductase family 1 member B1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:224794759-224795606 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:224810564-224810727 Neighboring gene CNIH3 antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:224825085-224825727 Neighboring gene DNAJB6 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr1:224885837-224886338 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:224920728-224921927 Neighboring gene CNIH3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2617 Neighboring gene uncharacterized LOC124904523 Neighboring gene long intergenic non-protein coding RNA 2813

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein cornichon homolog 3
    Names
    cornichon homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322302.2NP_001309231.1  protein cornichon homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099790, AL596330
      Conserved Domains (1) summary
      pfam03311
      Location:56179
      Cornichon; Cornichon protein
    2. NM_001322303.2NP_001309232.1  protein cornichon homolog 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC099790, AL596330
      Conserved Domains (1) summary
      pfam03311
      Location:27157
      Cornichon; Cornichon protein
    3. NM_001322304.2NP_001309233.1  protein cornichon homolog 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
      Conserved Domains (1) summary
      pfam03311
      Location:10133
      Cornichon; Cornichon protein
    4. NM_001322305.2NP_001309234.1  protein cornichon homolog 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC096537, AL596330
      Conserved Domains (1) summary
      pfam03311
      Location:7135
      Cornichon; Cornichon protein
    5. NM_152495.2NP_689708.1  protein cornichon homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_689708.1

      Status: VALIDATED

      Source sequence(s)
      AC096537, AK096312, AL596330
      Consensus CDS
      CCDS1544.1
      UniProtKB/Swiss-Prot
      Q8TBE1
      Related
      ENSP00000272133.3, ENST00000272133.4
      Conserved Domains (1) summary
      pfam03311
      Location:7151
      Cornichon; Cornichon protein

    RNA

    1. NR_136287.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AL596330
    2. NR_136288.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    3. NR_136289.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    4. NR_136290.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    5. NR_136291.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    6. NR_136292.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    7. NR_136293.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    8. NR_136294.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    9. NR_136295.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    10. NR_136296.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330
    11. NR_136297.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC096537, AC099790, AL596330

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      224434640..224740554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      223623489..223929352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)