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    CCN2 cellular communication network factor 2 [ Homo sapiens (human) ]

    Gene ID: 1490, updated on 17-Jun-2024

    Summary

    Official Symbol
    CCN2provided by HGNC
    Official Full Name
    cellular communication network factor 2provided by HGNC
    Primary source
    HGNC:HGNC:2500
    See related
    Ensembl:ENSG00000118523 MIM:121009; AllianceGenome:HGNC:2500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTGF; NOV2; HCS24; IBP-8; IGFBP8
    Summary
    The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]
    Expression
    Broad expression in spleen (RPKM 355.2), gall bladder (RPKM 303.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See CCN2 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (131948176..131951372, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133143212..133146410, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132269316..132272512, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit B pseudogene Neighboring gene RN7SK pseudogene 245 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:132180698-132181244 Neighboring gene HNF4 motif-containing MPRA enhancer 74 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132222462-132223015 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:132223016-132223568 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132228019-132228545 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:132228546-132229072 Neighboring gene Sharpr-MPRA regulatory region 1543 Neighboring gene CCN2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2799 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132324214-132325413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25069 Neighboring gene microRNA 548aj-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:132453077-132454276 Neighboring gene long intergenic non-protein coding RNA 1013

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102839

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    CCN family member 2
    Names
    IGF-binding protein 8
    connective tissue growth factor
    hypertrophic chondrocyte-specific protein 24
    insulin-like growth factor-binding protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016131.2 RefSeqGene

      Range
      5000..8196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001901.4NP_001892.2  CCN family member 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL354866
      Consensus CDS
      CCDS5151.1
      UniProtKB/Swiss-Prot
      E1P578, P29279, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
      UniProtKB/TrEMBL
      Q5M8T4
      Related
      ENSP00000356954.3, ENST00000367976.4
      Conserved Domains (4) summary
      pfam00093
      Location:103163
      VWC; von Willebrand factor type C domain
      pfam00219
      Location:2982
      IGFBP; Insulin-like growth factor binding protein
      pfam19035
      Location:199242
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:253345
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      131948176..131951372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133143212..133146410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)