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    CTBP1 C-terminal binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 1487, updated on 4-Jul-2021

    Summary

    Official Symbol
    CTBP1provided by HGNC
    Official Full Name
    C-terminal binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:2494
    See related
    Ensembl:ENSG00000159692 MIM:602618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BARS; HADDTS
    Summary
    This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CTBP1 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (1211444..1250355, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1205233..1244143, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374344 Neighboring gene transmembrane p24 trafficking protein 11, pseudogene Neighboring gene spondin 2 Neighboring gene uncharacterized LOC100130872 Neighboring gene CTBP1 antisense RNA Neighboring gene CTBP1 divergent transcript Neighboring gene uncharacterized LOC105374347 Neighboring gene uncharacterized LOC105374346 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of C-terminal binding protein 1 (CTBP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC104684

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables NAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    C-terminal-binding protein 1
    Names
    brefeldin A-ribosylated substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052824.1 RefSeqGene

      Range
      6200..43885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012614.2NP_001012632.1  C-terminal-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001012632.1

      Status: REVIEWED

      Source sequence(s)
      AC092535, BC011655, BC053320, BM989059, BU553431
      Consensus CDS
      CCDS43203.1
      UniProtKB/Swiss-Prot
      Q13363
      Related
      ENSP00000372411.3, ENST00000382952.8
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. NM_001328.3NP_001319.1  C-terminal-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001319.1

      Status: REVIEWED

      Source sequence(s)
      AC092535, BC011655, BM989059, BU553431, U37408
      Consensus CDS
      CCDS3348.1
      UniProtKB/Swiss-Prot
      Q13363
      UniProtKB/TrEMBL
      X5D8Y5
      Related
      ENSP00000290921.6, ENST00000290921.10
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. NM_001377186.1NP_001364115.1  C-terminal-binding protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    4. NM_001377187.1NP_001364116.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    5. NM_001377188.1NP_001364117.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    6. NM_001377189.1NP_001364118.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    7. NM_001377190.1NP_001364119.1  C-terminal-binding protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    8. NM_001377191.1NP_001364120.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    9. NM_001377192.1NP_001364121.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    10. NM_001377193.1NP_001364122.1  C-terminal-binding protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC092535
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      1211444..1250355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007764.1XP_016863253.1  C-terminal-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q13363
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. XM_005272263.5XP_005272320.1  C-terminal-binding protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005272320.1

      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. XM_024453899.1XP_024309667.1  C-terminal-binding protein 1 isoform X4

      Conserved Domains (1) summary
      cd05299
      Location:7272
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
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