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    Gspt1 G1 to S phase transition 1 [ Mus musculus (house mouse) ]

    Gene ID: 14852, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gspt1provided by MGI
    Official Full Name
    G1 to S phase transition 1provided by MGI
    Primary source
    MGI:MGI:1316728
    See related
    Ensembl:ENSMUSG00000062203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G1st; Gst-1; C79774; AI314175; AI326449; AV307676
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.1), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gspt1 in Genome Data Viewer
    Location:
    16 A1; 16 6.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (11216240..11254325, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (11216333..11254418, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene Wdr45 like pseudogene Neighboring gene RIKEN cDNA 2610020C07 gene Neighboring gene ribosomal L1 domain containing 1 Neighboring gene microRNA 1945 Neighboring gene tumor necrosis factor receptor superfamily, member 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36230, MGC36735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cytoplasmic translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Names
    G1 to S phase transition protein 1 homolog
    G1 to phase transition 1
    G1-to-S transition GTP binding protein
    eRF3a
    eukaryotic peptide chain release factor subunit 3a
    eukaryotic polypeptide chain release factor 3
    guanine nucleotide regulatory protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130008.1NP_001123480.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

      See identical proteins and their annotated locations for NP_001123480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in an internal exon, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AC087541, AK032059, AK148603, BB631229, CJ260597
      Consensus CDS
      CCDS49764.1
      UniProtKB/Swiss-Prot
      Q8R050
      UniProtKB/TrEMBL
      Q8CCV1
      Related
      ENSMUSP00000130583.1, ENSMUST00000167571.7
      Conserved Domains (5) summary
      cd01883
      Location:212428
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:208632
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:6481
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:437518
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:524630
      eRF3_C_III; C-terminal domain of eRF3
    2. NM_146066.2NP_666178.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

      See identical proteins and their annotated locations for NP_666178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC087541, AK148603, BB631229, CJ260597
      Consensus CDS
      CCDS27961.2
      UniProtKB/Swiss-Prot
      Q8R050
      Related
      ENSMUSP00000078940.7, ENSMUST00000080030.13
      Conserved Domains (5) summary
      cd01883
      Location:213429
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:209633
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:6481
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:438519
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:525631
      eRF3_C_III; C-terminal domain of eRF3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      11216240..11254325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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