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    Hspa5 heat shock protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 14828, updated on 3-Feb-2019

    Summary

    Official Symbol
    Hspa5provided by MGI
    Official Full Name
    heat shock protein 5provided by MGI
    Primary source
    MGI:MGI:95835
    See related
    Ensembl:ENSMUSG00000026864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; AL022860; AU019543; D2Wsu17e; D2Wsu141e
    Expression
    Ubiquitous expression in placenta adult (RPKM 321.6), genital fat pad adult (RPKM 154.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hspa5 in Genome Data Viewer
    Location:
    2 B; 2 22.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (34772090..34776529)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34627610..34632049)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene F-box and WD-40 domain protein 2 Neighboring gene predicted gene, 34653

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity, coupled IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of protein localization in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of embryonic development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posttranslational protein targeting to membrane, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum chaperone complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endoplasmic reticulum chaperone BiP
    Names
    78 kDa glucose-regulated protein
    GRP-78
    HSP70 family protein 5
    XAP-1 antigen
    binding-immunoglobulin protein
    glucose regulated protein, 78 kDa
    heat shock 70 kDa protein 5
    heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
    heat shock protein 70 family protein 5
    heat shock protein family A member 5
    immunoglobulin heavy chain-binding protein
    NP_001156906.1
    NP_071705.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163434.1NP_001156906.1  endoplasmic reticulum chaperone BiP precursor

      See identical proteins and their annotated locations for NP_001156906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK148539, AL929106
      Consensus CDS
      CCDS15950.1
      UniProtKB/Swiss-Prot
      P20029
      Related
      ENSMUSP00000028222.6, ENSMUST00000028222.12
      Conserved Domains (1) summary
      pfam00012
      Location:31636
      HSP70; Hsp70 protein
    2. NM_022310.3NP_071705.3  endoplasmic reticulum chaperone BiP precursor

      See identical proteins and their annotated locations for NP_071705.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK152521, AL929106
      Consensus CDS
      CCDS15950.1
      UniProtKB/Swiss-Prot
      P20029
      UniProtKB/TrEMBL
      Q3U7T8
      Related
      ENSMUSP00000097747.2, ENSMUST00000100171.2
      Conserved Domains (1) summary
      pfam00012
      Location:31636
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      34772090..34776529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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