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    Aes amino-terminal enhancer of split [ Mus musculus (house mouse) ]

    Gene ID: 14797, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aesprovided by MGI
    Official Full Name
    amino-terminal enhancer of splitprovided by MGI
    Primary source
    MGI:MGI:95806
    See related
    Ensembl:ENSMUSG00000054452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grg; Esp1; Grg5; Tle5; Grg-5; AL024115
    Summary
    This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 1208.9), duodenum adult (RPKM 833.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Aes in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (81559444..81566371)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (81022305..81029109)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene guanine nucleotide binding protein, alpha 11 Neighboring gene predicted gene, 31936 Neighboring gene transducin-like enhancer of split 2 Neighboring gene transducin-like enhancer of split 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    repressing transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to extracellular stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    amino-terminal enhancer of split
    Names
    groucho-related protein 5
    related to Drosophila groucho

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276288.1NP_001263217.1  amino-terminal enhancer of split isoform 2

      See identical proteins and their annotated locations for NP_001263217.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK158714, BC145299, BQ174071, BY713872
      UniProtKB/TrEMBL
      B7ZNK7, Q3TYD9
      Conserved Domains (1) summary
      pfam03920
      Location:2131
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. NM_010347.4NP_034477.1  amino-terminal enhancer of split isoform 1

      See identical proteins and their annotated locations for NP_034477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK158714, BQ174071, BY713872
      Consensus CDS
      CCDS24062.1
      UniProtKB/Swiss-Prot
      P63002
      UniProtKB/TrEMBL
      Q3TYD9
      Related
      ENSMUSP00000002518.8, ENSMUST00000002518.8
      Conserved Domains (1) summary
      pfam03920
      Location:2132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RNA

    1. NR_074087.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK158714, BE685863, BQ174071, BY713872

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      81559444..81566371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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