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    Grb2 growth factor receptor bound protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14784, updated on 26-Sep-2022

    Summary

    Official Symbol
    Grb2provided by MGI
    Official Full Name
    growth factor receptor bound protein 2provided by MGI
    Primary source
    MGI:MGI:95805
    See related
    Ensembl:ENSMUSG00000059923 AllianceGenome:MGI:95805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ash
    Summary
    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 40.7), frontal lobe adult (RPKM 37.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Grb2 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115534871..115599423, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115644045..115708597, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene predicted gene, 42096 Neighboring gene predicted gene 11703 Neighboring gene predicted gene, 23699

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular function activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotrophin TRKA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Grb2-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    growth factor receptor-bound protein 2
    Names
    SH2/SH3 adapter GRB2
    adapter protein GRB2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313936.1NP_001300865.1  growth factor receptor-bound protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK155800, BC052377, BQ174314, BY292622
      Consensus CDS
      CCDS25645.1
      UniProtKB/Swiss-Prot
      Q60631, Q61240
      UniProtKB/TrEMBL
      A0A6P5QTC6, A0A8C6N416, Q3U1Q4, Q3U5I5
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    2. NM_001313937.1NP_001300866.1  growth factor receptor-bound protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK155800, BC052377, BQ174314, BY266228
      Consensus CDS
      CCDS25645.1
      UniProtKB/Swiss-Prot
      Q60631, Q61240
      UniProtKB/TrEMBL
      A0A6P5QTC6, A0A8C6N416, Q3U1Q4, Q3U5I5
      Related
      ENSMUSP00000102106.2, ENSMUST00000106497.8
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    3. NM_008163.4NP_032189.1  growth factor receptor-bound protein 2

      See identical proteins and their annotated locations for NP_032189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK155800, BC052377, BQ174314
      Consensus CDS
      CCDS25645.1
      UniProtKB/Swiss-Prot
      Q60631, Q61240
      UniProtKB/TrEMBL
      A0A6P5QTC6, A0A8C6N416, Q3U1Q4, Q3U5I5
      Related
      ENSMUSP00000021090.8, ENSMUST00000021090.14
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115534871..115599423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)