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    Gpx3 glutathione peroxidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 14778, updated on 16-Aug-2021

    Summary

    Official Symbol
    Gpx3provided by MGI
    Official Full Name
    glutathione peroxidase 3provided by MGI
    Primary source
    MGI:MGI:105102
    See related
    Ensembl:ENSMUSG00000018339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP; EGP; GPx; EGPx; GSHPx-3; GSHPx-P; AA960521
    Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in kidney adult (RPKM 11946.2) and genital fat pad adult (RPKM 610.3) See more
    Orthologs
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    Genomic context

    See Gpx3 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54793680..54801213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54902854..54910387)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54716355..54723889)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 40S ribosomal protein S11-like Neighboring gene annexin A6 Neighboring gene predicted gene, 19911

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
     
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables selenium binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
     
    involved_in hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione peroxidase 3
    Names
    GPx-3
    GPx-P
    extracellular GPx
    plasma GPx
    plasma glutathione peroxidase
    NP_001316789.1
    NP_032187.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329860.1NP_001316789.1  glutathione peroxidase 3 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. The resulting isoform (2) is longer, containing a 32 aa protein segment not found in isoform 1.
      Source sequence(s)
      AK004942, AW319411, BG796554, BY061328
      UniProtKB/Swiss-Prot
      P46412
      Related
      ENSMUSP00000119882.3, ENSMUST00000149324.3
    2. NM_008161.4NP_032187.2  glutathione peroxidase 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032187.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AK004942, BG796554, BY061328
      Consensus CDS
      CCDS24703.1
      UniProtKB/Swiss-Prot
      P46412
      Related
      ENSMUSP00000081011.5, ENSMUST00000082430.11
      Conserved Domains (1) summary
      cd00340
      Location:39211
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54793680..54801213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001083929.1: Suppressed sequence

      Description
      NM_001083929.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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