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    Grk5 G protein-coupled receptor kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 14773, updated on 19-Mar-2019

    Summary

    Official Symbol
    Grk5provided by MGI
    Official Full Name
    G protein-coupled receptor kinase 5provided by MGI
    Primary source
    MGI:MGI:109161
    See related
    Ensembl:ENSMUSG00000003228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gprk5
    Expression
    Ubiquitous expression in lung adult (RPKM 3.7), subcutaneous fat pad adult (RPKM 2.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Grk5 in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (60889610..61095968)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (60965652..61168459)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene peroxiredoxin 3 Neighboring gene predicted gene, 41885 Neighboring gene predicted gene 9529 Neighboring gene zinc finger protein 950 Neighboring gene ribosomal protein S25 pseudogene Neighboring gene predicted gene 6020 Neighboring gene mortality factor 4 like 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-adrenergic receptor kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    desensitization of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    tachykinin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 5
    Names
    g protein-coupled receptor kinase GRK5
    NP_061357.3
    XP_006526760.1
    XP_011245451.1
    XP_017173555.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018869.3NP_061357.3  G protein-coupled receptor kinase 5

      See identical proteins and their annotated locations for NP_061357.3

      Status: VALIDATED

      Source sequence(s)
      AK135076, AK161821, AW456000, BY289760
      Consensus CDS
      CCDS29945.1
      UniProtKB/Swiss-Prot
      Q8VEB1
      UniProtKB/TrEMBL
      Q3TST4
      Related
      ENSMUSP00000003313.8, ENSMUST00000003313.8
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:183495
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:53175
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      60889610..61095968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526697.3XP_006526760.1  G protein-coupled receptor kinase 5 isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:151463
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:21143
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_011247149.2XP_011245451.1  G protein-coupled receptor kinase 5 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:139401
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05632
      Location:136448
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:6128
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. XM_017318066.1XP_017173555.1  G protein-coupled receptor kinase 5 isoform X3

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