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    Pdpn podoplanin [ Mus musculus (house mouse) ]

    Gene ID: 14726, updated on 6-Jul-2021

    Summary

    Official Symbol
    Pdpnprovided by MGI
    Official Full Name
    podoplaninprovided by MGI
    Primary source
    MGI:MGI:103098
    See related
    Ensembl:ENSMUSG00000028583
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T1; E11; Gp3; OTS; T1a; Gp38; PA2.; RAND; OTS-8; T1alpha; RANDAM-2; T1-alpha
    Expression
    Broad expression in bladder adult (RPKM 24.1), placenta adult (RPKM 24.0) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdpn in Genome Data Viewer
    Location:
    4; 4 E1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (142993979..143026134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (143267409..143299564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (142857325..142889410, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52493 Neighboring gene eukaryotic translation elongation factor 2, pseudogene 2 Neighboring gene leucine rich repeat containing 38 Neighboring gene Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables folic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables water transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin-mediated cell contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin-mediated cell contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in folic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphatic endothelial cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular component movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of platelet aggregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostaglandin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of lamellipodium morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myofibroblast contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of myofibroblast contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hyperoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visceral serous pericardium development TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT acts_upstream_of_or_within water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge of lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tetraspanin-enriched microdomain ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    podoplanin
    Names
    PA2.26 antigen
    aggrus
    glycoprotein 38
    transmembrane glycoprotein E11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290822.1NP_001277751.1  podoplanin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK158855, AL611982, CX240531
      Consensus CDS
      CCDS71511.1
      UniProtKB/Swiss-Prot
      Q62011
      UniProtKB/TrEMBL
      A8Y5F6
      Related
      ENSMUSP00000113776.2, ENSMUST00000119654.2
      Conserved Domains (1) summary
      pfam05808
      Location:1158
      Podoplanin; Podoplanin
    2. NM_010329.3NP_034459.2  podoplanin isoform 1 precursor

      See identical proteins and their annotated locations for NP_034459.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158855, AL611982
      Consensus CDS
      CCDS38943.1
      UniProtKB/Swiss-Prot
      Q62011
      Related
      ENSMUSP00000030317.8, ENSMUST00000030317.14
      Conserved Domains (1) summary
      pfam05808
      Location:1171
      Podoplanin; Podoplanin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      142993979..143026134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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