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    Gnb2 guanine nucleotide binding protein (G protein), beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 14693, updated on 18-Sep-2018

    Summary

    Official Symbol
    Gnb2provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), beta 2provided by MGI
    Primary source
    MGI:MGI:95784
    See related
    Ensembl:ENSMUSG00000029713 Vega:OTTMUSG00000016277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnb-2
    Expression
    Ubiquitous expression in ovary adult (RPKM 211.7), adrenal adult (RPKM 206.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gnb2 in Genome Data Viewer
    Location:
    5 G2; 5 76.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (137528129..137533229, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137969357..137974457, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene processing of precursor 7, ribonuclease P family, (S. cerevisiae) Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene microRNA 6418 Neighboring gene actin-like 6B Neighboring gene transferrin receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
    Names
    g protein subunit beta-2
    guanine nucleotide binding protein, beta 2
    guanine nucleotide-binding protein, beta-2 subunit
    transducin beta chain 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010312.5NP_034442.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

      See identical proteins and their annotated locations for NP_034442.1

      Status: VALIDATED

      Source sequence(s)
      AI892088, AK146941, BF458455
      Consensus CDS
      CCDS19769.1
      UniProtKB/Swiss-Prot
      P62880
      UniProtKB/TrEMBL
      Q3U9V4
      Related
      ENSMUSP00000031726.8, OTTMUSP00000017447, ENSMUST00000031726.14
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      137528129..137533229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504553.3XP_006504616.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006504616.1

      UniProtKB/Swiss-Prot
      P62880
      UniProtKB/TrEMBL
      Q3U9V4
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
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