Format

Send to:

Choose Destination
    • Showing Current items.

    Gnb2 guanine nucleotide binding protein (G protein), beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 14693, updated on 8-Aug-2021

    Summary

    Official Symbol
    Gnb2provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), beta 2provided by MGI
    Primary source
    MGI:MGI:95784
    See related
    Ensembl:ENSMUSG00000029713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnb-2
    Expression
    Ubiquitous expression in ovary adult (RPKM 211.7), adrenal adult (RPKM 206.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gnb2 in Genome Data Viewer
    Location:
    5 G2; 5 76.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137526389..137533085, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137528127..137533449, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137969357..137974457, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene processing of precursor 7, ribonuclease P family, (S. cerevisiae) Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene microRNA 6418 Neighboring gene predicted gene 17112 Neighboring gene actin-like 6B Neighboring gene transferrin receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
    Names
    g protein subunit beta-2
    guanine nucleotide binding protein, beta 2
    guanine nucleotide-binding protein, beta-2 subunit
    transducin beta chain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010312.5NP_034442.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

      See identical proteins and their annotated locations for NP_034442.1

      Status: VALIDATED

      Source sequence(s)
      AI892088, AK146941, BF458455
      Consensus CDS
      CCDS19769.1
      UniProtKB/Swiss-Prot
      P62880
      UniProtKB/TrEMBL
      Q3U9V4
      Related
      ENSMUSP00000031726.9, ENSMUST00000031726.15
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137526389..137533085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504553.5XP_006504616.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006504616.1

      UniProtKB/Swiss-Prot
      P62880
      UniProtKB/TrEMBL
      Q3U9V4
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    Support Center