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    Gnb1 guanine nucleotide binding protein (G protein), beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14688, updated on 9-Oct-2018

    Summary

    Official Symbol
    Gnb1provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), beta 1provided by MGI
    Primary source
    MGI:MGI:95781
    See related
    Ensembl:ENSMUSG00000029064 Vega:OTTMUSG00000010708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnb-1; C77571; AA409223
    Expression
    Ubiquitous expression in CNS E18 (RPKM 188.2), large intestine adult (RPKM 186.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gnb1 in Genome Data Viewer
    Location:
    4 E2; 4 86.17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (155491361..155559269)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154865470..154933378)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene cilia and flagella associated protein 74 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene NAD kinase Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC98074

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    alkylglycerophosphoethanolamine phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phototransduction, visible light ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterotrimerization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of taste IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    heterotrimeric G-protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Names
    guanine nucleotide binding protein, beta 1
    transducin beta chain 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160016.1NP_001153488.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_001153488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AK163844, AL627405, AL670227, U29055
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70
      Related
      ENSMUSP00000030940.7, OTTMUSP00000011446, ENSMUST00000030940.13, OTTMUST00000024981
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    2. NM_001160017.1NP_001153489.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_001153489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, compared to variant 1. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AL627405, AL670227, BG807492, U29055
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70
      Related
      ENSMUSP00000101241.3, OTTMUSP00000055795, ENSMUST00000105616.9, OTTMUST00000099383
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    3. NM_008142.4NP_032168.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_032168.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same the protein.
      Source sequence(s)
      AK163844, AL627405, AL670227
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70
      Related
      ENSMUSP00000130123.1, ENSMUST00000165335.7
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      155491361..155559269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319977.1XP_017175466.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70
      Related
      ENSMUSP00000135091.1, OTTMUSP00000055798, ENSMUST00000176637.1, OTTMUST00000099389
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
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