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    SLC25A10 solute carrier family 25 member 10 [ Homo sapiens (human) ]

    Gene ID: 1468, updated on 2-May-2024

    Summary

    Official Symbol
    SLC25A10provided by HGNC
    Official Full Name
    solute carrier family 25 member 10provided by HGNC
    Primary source
    HGNC:HGNC:10980
    See related
    Ensembl:ENSG00000183048 MIM:606794; AllianceGenome:HGNC:10980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIC; MTDPS19
    Summary
    This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    17q25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81712284..81721012)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82629200..82637941)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79679314..79688042)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79667464-79668068 Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79668069-79668672 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79669277-79669880 Neighboring gene microRNA 6786 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79669881-79670484 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79677211-79677911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9150 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79689497-79690038 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:79697182-79697401 Neighboring gene uncharacterized LOC105371929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79699122-79699658 Neighboring gene uncharacterized LOC105376789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79761495-79761994 Neighboring gene glucagon receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mitochondrial DNA depletion syndrome 19
    MedGen: C5436514 OMIM: 618972 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dicarboxylic acid transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables dicarboxylic acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables malate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in dicarboxylic acid transport TAS
    Traceable Author Statement
    more info
     
    involved_in gluconeogenesis TAS
    Traceable Author Statement
    more info
     
    involved_in glyceraldehyde-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in malate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfide oxidation, using sulfide:quinone oxidoreductase TAS
    Traceable Author Statement
    more info
     
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    mitochondrial dicarboxylate carrier
    Names
    dicarboxylate ion carrier
    solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270888.2NP_001257817.1  mitochondrial dicarboxylate carrier isoform 1

      See identical proteins and their annotated locations for NP_001257817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC015797, HY259124
      Consensus CDS
      CCDS59301.1
      UniProtKB/TrEMBL
      A0A0S2Z3G3
      Related
      ENSP00000328403.5, ENST00000331531.9
      Conserved Domains (1) summary
      pfam00153
      Location:95190
      Mito_carr; Mitochondrial carrier protein
    2. NM_001270953.2NP_001257882.1  mitochondrial dicarboxylate carrier isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC007355, BM561945, HY259124
      Consensus CDS
      CCDS74176.1
      UniProtKB/TrEMBL
      F6RGN5
      Related
      ENSP00000446242.2, ENST00000545862.5
      Conserved Domains (1) summary
      pfam00153
      Location:1393
      Mito_carr; Mitochondrial carrier protein
    3. NM_012140.5NP_036272.2  mitochondrial dicarboxylate carrier isoform 2

      See identical proteins and their annotated locations for NP_036272.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC139530, AI081980, BC007355, HY259124
      Consensus CDS
      CCDS11786.1
      UniProtKB/Swiss-Prot
      Q542Z3, Q96BA1, Q96IP1, Q9UBX3
      UniProtKB/TrEMBL
      A0A0S2Z382
      Related
      ENSP00000345580.5, ENST00000350690.10
      Conserved Domains (1) summary
      pfam00153
      Location:198284
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81712284..81721012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435431.1XP_047291387.1  mitochondrial dicarboxylate carrier isoform X1

    2. XM_047435432.1XP_047291388.1  mitochondrial dicarboxylate carrier isoform X2

      UniProtKB/TrEMBL
      B4E1E9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82629200..82637941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315161.1XP_054171136.1  mitochondrial dicarboxylate carrier isoform X1

    2. XM_054315162.1XP_054171137.1  mitochondrial dicarboxylate carrier isoform X2

      UniProtKB/TrEMBL
      B4E1E9