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    Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 [ Mus musculus (house mouse) ]

    Gene ID: 14677, updated on 22-Aug-2021

    Summary

    Official Symbol
    Gnai1provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), alpha inhibiting 1provided by MGI
    Primary source
    MGI:MGI:95771
    See related
    Ensembl:ENSMUSG00000057614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gia; Gnai-1; AU046200; Gialpha1
    Expression
    Broad expression in frontal lobe adult (RPKM 36.7), cerebellum adult (RPKM 28.5) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Gnai1 in Genome Data Viewer
    Location:
    5 A3; 5 8.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (18470133..18565411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (18265135..18360413, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (17770953..17866231, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31612 Neighboring gene guanine nucleotide binding protein, alpha transducing 3 Neighboring gene predicted gene, 54321 Neighboring gene predicted gene 3527 Neighboring gene predicted gene, 31752 Neighboring gene transketolase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled serotonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled serotonin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(i) subunit alpha-1
    Names
    adenylate cyclase-inhibiting G alpha protein
    guanine nucleotide binding protein, alpha inhibiting 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010305.1NP_034435.1  guanine nucleotide-binding protein G(i) subunit alpha-1

      See identical proteins and their annotated locations for NP_034435.1

      Status: VALIDATED

      Source sequence(s)
      AC116505, BC032995, BY740128
      Consensus CDS
      CCDS39018.1
      UniProtKB/Swiss-Prot
      B2RSH2
      Related
      ENSMUSP00000074259.6, ENSMUST00000074694.7
      Conserved Domains (1) summary
      cd00066
      Location:34348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      18470133..18565411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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