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    Gna12 guanine nucleotide binding protein, alpha 12 [ Mus musculus (house mouse) ]

    Gene ID: 14673, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gna12provided by MGI
    Official Full Name
    guanine nucleotide binding protein, alpha 12provided by MGI
    Primary source
    MGI:MGI:95767
    See related
    Ensembl:ENSMUSG00000000149 AllianceGenome:MGI:95767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galpha12
    Summary
    Predicted to enable several functions, including D5 dopamine receptor binding activity; G protein activity; and G-protein beta/gamma-subunit complex binding activity. Involved in several processes, including regulation of TOR signaling; regulation of fibroblast migration; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including Rho protein signal transduction; embryonic digit morphogenesis; and regulation of cell shape. Predicted to be located in lateral plasma membrane; neuron projection; and neuronal cell body. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane and cytoplasm. Is expressed in several structures, including branchial arch; central nervous system; female reproductive system; heart; and retina. Orthologous to human GNA12 (G protein subunit alpha 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 67.3), ovary adult (RPKM 61.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gna12 in Genome Data Viewer
    Location:
    5 G2; 5 79.3 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140745699..140816186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140759944..140830431, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11307 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene predicted gene, 30745 Neighboring gene STARR-positive B cell enhancer ABC_E282 Neighboring gene predicted gene, 52831 Neighboring gene predicted gene, 30804 Neighboring gene caspase recruitment domain family, member 11 Neighboring gene STARR-positive B cell enhancer ABC_E1697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141424066-141424354 Neighboring gene STARR-positive B cell enhancer mm9_chr5:141427775-141428076 Neighboring gene STARR-positive B cell enhancer ABC_E9658

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Amz1

    Clone Names

    • MGC130498

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D5 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D5 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit alpha-12
    Names
    G-protein subunit alpha-12
    g alpha-12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010302.2NP_034432.1  guanine nucleotide-binding protein subunit alpha-12

      See identical proteins and their annotated locations for NP_034432.1

      Status: PROVISIONAL

      Source sequence(s)
      AC158914
      Consensus CDS
      CCDS19825.1
      UniProtKB/Swiss-Prot
      P27600
      UniProtKB/TrEMBL
      A0A0G2JG40
      Related
      ENSMUSP00000000153.5, ENSMUST00000000153.9
      Conserved Domains (1) summary
      smart00275
      Location:40377
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140745699..140816186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)