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    Glud1 glutamate dehydrogenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14661, updated on 9-Aug-2021

    Summary

    Official Symbol
    Glud1provided by MGI
    Official Full Name
    glutamate dehydrogenase 1provided by MGI
    Primary source
    MGI:MGI:95753
    See related
    Ensembl:ENSMUSG00000021794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glu; Glud; Gdh-X; Gludl; AI118167
    Expression
    Ubiquitous expression in liver adult (RPKM 291.2), liver E18 (RPKM 185.4) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Glud1 in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34032684..34066990)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34310727..34345033)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (35123913..35158219)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin XV Neighboring gene shieldin complex subunit 2 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene B-cell CLL/lymphoma 7C pseudogene Neighboring gene family with sequence similarity 25, member C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutamate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables leucine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to aluminum ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate dehydrogenase 1, mitochondrial
    Names
    GDH 1
    NP_032159.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008133.4NP_032159.1  glutamate dehydrogenase 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032159.1

      Status: VALIDATED

      Source sequence(s)
      AK089152, AK150637, AK161876
      Consensus CDS
      CCDS26935.1
      UniProtKB/Swiss-Prot
      P26443
      UniProtKB/TrEMBL
      Q3TSQ7
      Related
      ENSMUSP00000022322.10, ENSMUST00000022322.17
      Conserved Domains (1) summary
      COG0334
      Location:104546
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      34032684..34066990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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