Glp1r glucagon-like peptide 1 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glp1rprovided by MGI
Official Full Name: glucagon-like peptide 1 receptorprovided by MGI
Primary source: MGI:MGI:99571
See related: Ensembl:ENSMUSG00000024027 AllianceGenome:MGI:99571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GLP-1R; GLP1Rc
Summary: Predicted to enable glucagon-like peptide 1 receptor activity and peptide hormone binding activity. Involved in several processes, including learning or memory; positive regulation of blood pressure; and response to psychosocial stress. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 40.4), duodenum adult (RPKM 18.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31120841..31155484)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (30901867..30936510)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal GLP-1 receptor activation inhibits fetal growth.
Title: Maternal GLP-1 receptor activation inhibits fetal growth.
Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.
Title: Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Title: Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.
Title: Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.
Cerebral glucagon-like peptide-1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice.
Title: Cerebral glucagon-like peptide-1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice.
The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.
Title: The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.
Divergent acute versus prolonged pharmacological GLP-1R responses in adult beta cell-specific beta-arrestin 2 knockout mice.
Title: Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice.
Glucagon Acting at the GLP-1 Receptor Contributes to beta-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice.
Title: Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice.
Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice.
Title: Acute Inhibition of Intestinal Neprilysin Enhances Insulin Secretion via GLP-1 Receptor Signaling in Male Mice.
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.
Title: Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.

Submit: New GeneRIF Correction See all GeneRIFs (150)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489231

Glp1r (e-PCR), detects polymorphism
- UniSTS:257077

138017-T7 (e-PCR), detects polymorphism
- UniSTS:140891

Glp1r (e-PCR), detects polymorphism
- UniSTS:462685

D17Mit81 (e-PCR), detects polymorphism
- UniSTS:128106

Glp1r (e-PCR), detects polymorphism
- UniSTS:143221

D17Dcr3 (e-PCR), detects polymorphism
- UniSTS:507529

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon-like peptide 1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon-like peptide 1 receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-translational protein targeting to membrane, translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to psychosocial stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucagon-like peptide 1 receptor

Names: GLP-1 receptor; GLP-1-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021332.2 → NP_067307.2 glucagon-like peptide 1 receptor precursor

See identical proteins and their annotated locations for NP_067307.2

Status: VALIDATED

Source sequence(s)

DQ093397

Consensus CDS

CCDS37542.1

UniProtKB/Swiss-Prot

O35659, Q1JQR8

UniProtKB/TrEMBL

Q104P0, Q3ZAW0

Related

ENSMUSP00000110221.2, ENSMUST00000114574.3

Conserved Domains (2) summary

pfam00002
Location:141 → 398

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:59 → 128

HRM; Hormone receptor domain