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    Gclm glutamate-cysteine ligase, modifier subunit [ Mus musculus (house mouse) ]

    Gene ID: 14630, updated on 22-Aug-2021

    Summary

    Official Symbol
    Gclmprovided by MGI
    Official Full Name
    glutamate-cysteine ligase, modifier subunitprovided by MGI
    Primary source
    MGI:MGI:104995
    See related
    Ensembl:ENSMUSG00000028124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gl; Gcmc; Glclr; AI649393
    Expression
    Ubiquitous expression in duodenum adult (RPKM 93.5), liver E14 (RPKM 50.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Gclm in Genome Data Viewer
    Location:
    3 G1; 3 52.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122039206..122060864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (122245487..122267215)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (121948510..121969566)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46822 Neighboring gene predicted gene, 40137 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 3_1245.1 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 2 Neighboring gene nuclear encoded tRNA arginine 2 (anticodon TCT) Neighboring gene predicted gene, 40190

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-threo-aldose 1-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to glutamate-cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-cysteine ligase catalytic subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate-cysteine ligase catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glutamate-cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of glutamate-cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glutamate-cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to nitrosative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of glutamate-cysteine ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of glutamate-cysteine ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate--cysteine ligase regulatory subunit
    Names
    GCS light chain
    gamma-ECS regulatory subunit
    gamma-glutamylcysteine synthetase regulatory subunit
    NP_032155.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008129.4NP_032155.1  glutamate--cysteine ligase regulatory subunit

      See identical proteins and their annotated locations for NP_032155.1

      Status: VALIDATED

      Source sequence(s)
      AK028236, BB615104, DV659479
      Consensus CDS
      CCDS17808.1
      UniProtKB/Swiss-Prot
      O09172
      UniProtKB/TrEMBL
      Q4FJZ6
      Related
      ENSMUSP00000029769.8, ENSMUST00000029769.14
      Conserved Domains (1) summary
      cl00470
      Location:109211
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      122039206..122060864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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