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    Gclc glutamate-cysteine ligase, catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 14629, updated on 12-Feb-2019

    Summary

    Official Symbol
    Gclcprovided by MGI
    Official Full Name
    glutamate-cysteine ligase, catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:104990
    See related
    Ensembl:ENSMUSG00000032350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glclc; GLCL-H; Ggcs-hs; D9Wsu168e
    Expression
    Ubiquitous expression in liver adult (RPKM 50.5), kidney adult (RPKM 34.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gclc in Genome Data Viewer
    Location:
    9 E1; 9 43.36 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (77754518..77794489)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (77602617..77641458)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene chimerin (chimaerin) 1 pseudogene Neighboring gene kelch-like 31 Neighboring gene predicted gene, 34654 Neighboring gene spindle and kinetochore-associated protein 2-like Neighboring gene ELOVL family member 5, elongation of long chain fatty acids (yeast) Neighboring gene predicted gene, 34771

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate-cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamate-cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate-cysteine ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamate-cysteine ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    L-ascorbic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic mitochondrial changes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of hepatic stellate cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood vessel size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    response to nitrosative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamate-cysteine ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamate-cysteine ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate--cysteine ligase catalytic subunit
    Names
    GCS heavy chain
    gamma GCS-HS
    gamma-ECS
    gamma-glutamylcysteine synthetase heavy subunit
    NP_034425.1
    XP_006510875.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010295.2NP_034425.1  glutamate--cysteine ligase catalytic subunit

      See identical proteins and their annotated locations for NP_034425.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AK144339, AK160876, EH103060
      Consensus CDS
      CCDS23354.1
      UniProtKB/Swiss-Prot
      P97494
      UniProtKB/TrEMBL
      Q3TEF1, Q3UNA7
      Related
      ENSMUSP00000034905.8, ENSMUST00000034905.8
      Conserved Domains (1) summary
      pfam03074
      Location:236608
      GCS; Glutamate-cysteine ligase

    RNA

    1. NR_151778.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159886, AC160124

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      77754518..77794489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510812.1XP_006510875.1  glutamate--cysteine ligase catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam03074
      Location:183555
      GCS; Glutamate-cysteine ligase

    RNA

    1. XR_001778796.1 RNA Sequence

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