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    Gfpt1 glutamine fructose-6-phosphate transaminase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14583, updated on 16-Mar-2019

    Summary

    Official Symbol
    Gfpt1provided by MGI
    Official Full Name
    glutamine fructose-6-phosphate transaminase 1provided by MGI
    Primary source
    MGI:MGI:95698
    See related
    Ensembl:ENSMUSG00000029992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GFA; GFAT; Gfpt; GFAT1; GFAT1m; AI324119; AI449986; 2810423A18Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 40.5), large intestine adult (RPKM 20.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Gfpt1 in Genome Data Viewer
    Location:
    6 D1; 6 37.81 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (87042846..87092207)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (86992840..87042201)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene AP2 associated kinase 1 Neighboring gene predicted gene, 38495 Neighboring gene NFU1 iron-sulfur cluster scaffold Neighboring gene DNA segment, Chr 6, ERATO Doi 527, expressed Neighboring gene predicted gene, 40382

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    UDP-N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UDP-N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
    Names
    D-fructose-6-phosphate amidotransferase 1
    GFAT 1
    glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
    glutamine:fructose-6-phosphate amidotransferase 1
    hexosephosphate aminotransferase 1
    NP_038556.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013528.3NP_038556.1  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

      See identical proteins and their annotated locations for NP_038556.1

      Status: VALIDATED

      Source sequence(s)
      AC162465, AK019852, BB664274, CN664418
      Consensus CDS
      CCDS39545.1
      UniProtKB/Swiss-Prot
      P47856
      Related
      ENSMUSP00000109288.1, ENSMUST00000113658.7
      Conserved Domains (4) summary
      PLN02981
      Location:1681
      PLN02981; glucosamine:fructose-6-phosphate aminotransferase
      cd00714
      Location:2284
      GFAT; Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In ...
      cd05008
      Location:368493
      SIS_GlmS_GlmD_1; SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...
      cd05009
      Location:525679
      SIS_GlmS_GlmD_2; SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      87042846..87092207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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