Format

Send to:

Choose Destination
    • Showing Current items.

    Gpd2 glycerol phosphate dehydrogenase 2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 14571, updated on 31-Jan-2019

    Summary

    Official Symbol
    Gpd2provided by MGI
    Official Full Name
    glycerol phosphate dehydrogenase 2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:99778
    See related
    Ensembl:ENSMUSG00000026827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GPDH; Gdm1; Gpd-m; Gpdh-m; TISP38; AA408484; AI448216; AU021455; AW494132
    Expression
    Broad expression in testis adult (RPKM 48.2), mammary gland adult (RPKM 14.9) and 21 other tissues See more
    Orthologs

    Genomic context

    See Gpd2 in Genome Data Viewer
    Location:
    2 C1.1; 2 31.66 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (57237678..57370719)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (57090089..57223130)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E, pseudogene 4 Neighboring gene predicted gene, 39813 Neighboring gene cytoskeleton associated protein 2 pseudogene Neighboring gene predicted gene 13531 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycerol-3-phosphate dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol-3-phosphate dehydrogenase [NAD+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol-3-phosphate dehydrogenase [NAD+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerol-3-phosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycerol-3-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerol-3-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    glycerol-3-phosphate dehydrogenase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glycerol-3-phosphate dehydrogenase, mitochondrial
    Names
    FAD-linked glycerol-3-phosphate dehydrogenase
    glycerol phosphate dehydrogenase 1, mitochondrial
    glycerol-3-phosphate dehydrogenase 2, mitochondrial
    NP_001139292.1
    NP_034404.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145820.1NP_001139292.1  glycerol-3-phosphate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001139292.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AK032044, AK080240, AK144716
      Consensus CDS
      CCDS16045.1
      UniProtKB/Swiss-Prot
      Q64521
      Related
      ENSMUSP00000130992.1, ENSMUST00000169687.7
      Conserved Domains (4) summary
      PLN02464
      Location:1599
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:627689
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:629688
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:462588
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
    2. NM_010274.3NP_034404.3  glycerol-3-phosphate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_034404.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK032044, AK080240, AK144716, BY238564
      Consensus CDS
      CCDS16045.1
      UniProtKB/Swiss-Prot
      Q64521
      Related
      ENSMUSP00000028167.2, ENSMUST00000028167.2
      Conserved Domains (4) summary
      PLN02464
      Location:1599
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:627689
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:629688
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:462588
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      57237678..57370719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center