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    CSNK2A1 casein kinase 2 alpha 1 [ Homo sapiens (human) ]

    Gene ID: 1457, updated on 9-Jun-2024

    Summary

    Official Symbol
    CSNK2A1provided by HGNC
    Official Full Name
    casein kinase 2 alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:2457
    See related
    Ensembl:ENSG00000101266 MIM:115440; AllianceGenome:HGNC:2457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKII; Cka1; Cka2; CK2A1; OCNDS
    Summary
    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]
    Expression
    Ubiquitous expression in testis (RPKM 33.5), brain (RPKM 25.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CSNK2A1 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (472498..543790, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (516232..587494, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (453142..524434, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:388888-389530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:389531-390171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:410614-411114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:411115-411615 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene TBC1 domain family member 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:442560-442708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12578 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:456844-457048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:522754-523447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12579 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:524141-524834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:552949-553709 Neighboring gene Sharpr-MPRA regulatory region 14258 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:572175-572398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:591860-592360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:592361-592861 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:596343-597542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:601772-602601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:602602-603430 Neighboring gene transcription factor 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:614811-615388 Neighboring gene uncharacterized LOC107985423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12582 Neighboring gene sulfiredoxin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, casein kinase 2 alpha 1 polypeptide (CSNK2A1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A1 is decreased by RRE PubMed
    rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
    rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
    rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
    rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
    rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
    Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
    vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
    matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
    reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
    gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone-mediated protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in double-strand break repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of aggrephagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in symbiont-mediated disruption of host cell PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein kinase CK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein kinase CK2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein kinase CK2 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of protein kinase CK2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    casein kinase II subunit alpha
    Names
    CK2 catalytic subunit alpha
    casein kinase 2, alpha 1 polypeptide
    casein kinase II alpha 1 polypeptide pseudogene
    casein kinase II alpha 1 subunit
    protein kinase CK2
    NP_001349699.1
    NP_001349700.1
    NP_001886.1
    NP_808227.1
    NP_808228.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011970.2 RefSeqGene

      Range
      5049..76341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001362770.2NP_001349699.1  casein kinase II subunit alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AL049761
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
      UniProtKB/TrEMBL
      B2R6D7, B5BUH5
      Related
      ENSP00000495998.1, ENST00000645623.1
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    2. NM_001362771.2NP_001349700.1  casein kinase II subunit alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AL049761
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
      UniProtKB/TrEMBL
      B2R6D7, B5BUH5
      Related
      ENSP00000495248.1, ENST00000643660.1
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    3. NM_001895.4NP_001886.1  casein kinase II subunit alpha isoform a

      See identical proteins and their annotated locations for NP_001886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AL049761, AU133318, BC053532, M55265
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
      UniProtKB/TrEMBL
      B2R6D7, B5BUH5
      Related
      ENSP00000496569.1, ENST00000646561.1
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    4. NM_177559.3NP_808227.1  casein kinase II subunit alpha isoform a

      See identical proteins and their annotated locations for NP_808227.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same protein.
      Source sequence(s)
      AL049761, AU132198, BC053532, M55265
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
      UniProtKB/TrEMBL
      B2R6D7, B5BUH5
      Related
      ENSP00000217244.3, ENST00000217244.9
      Conserved Domains (1) summary
      cd14132
      Location:20325
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    5. NM_177560.3NP_808228.1  casein kinase II subunit alpha isoform b

      See identical proteins and their annotated locations for NP_808228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1, resulting in an isoform (b) which is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AL049761, AU132198, AY735339, BC053532, M55265
      Consensus CDS
      CCDS13004.1
      UniProtKB/Swiss-Prot
      P68400
      Related
      ENSP00000339247.6, ENST00000349736.10
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      472498..543790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      516232..587494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)