Format

Send to:

Choose Destination
    • Showing Current items.

    Gdf9 growth differentiation factor 9 [ Mus musculus (house mouse) ]

    Gene ID: 14566, updated on 31-Aug-2021

    Summary

    Official Symbol
    Gdf9provided by MGI
    Official Full Name
    growth differentiation factor 9provided by MGI
    Primary source
    MGI:MGI:95692
    See related
    Ensembl:ENSMUSG00000018238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdf-9
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in ovary adult (RPKM 37.3) and testis adult (RPKM 3.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gdf9 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53321773..53328731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53430774..53437904)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53246788..53251405)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene predicted gene, 30585 Neighboring gene shroom family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables type I activin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    growth/differentiation factor 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008110.2NP_032136.2  growth/differentiation factor 9 precursor

      See identical proteins and their annotated locations for NP_032136.2

      Status: REVIEWED

      Source sequence(s)
      AK136145, BC052667, CA559167
      Consensus CDS
      CCDS24679.1
      UniProtKB/Swiss-Prot
      Q07105
      UniProtKB/TrEMBL
      Q3UWR9, Q7TPZ4
      Related
      ENSMUSP00000018382.7, ENSMUST00000018382.7
      Conserved Domains (1) summary
      cd19403
      Location:336441
      TGF_beta_GDF9; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53321773..53328731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532220.5XP_006532283.1  growth/differentiation factor 9 isoform X2

      Conserved Domains (1) summary
      cd19403
      Location:248353
      TGF_beta_GDF9; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins
    2. XM_030245570.2XP_030101430.1  growth/differentiation factor 9 isoform X1

      Conserved Domains (1) summary
      cd19403
      Location:336441
      TGF_beta_GDF9; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins
    3. XM_006532221.5XP_006532284.1  growth/differentiation factor 9 isoform X3

      Conserved Domains (1) summary
      cd19403
      Location:200305
      TGF_beta_GDF9; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins
    Support Center