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    Gdf9 growth differentiation factor 9 [ Mus musculus (house mouse) ]

    Gene ID: 14566, updated on 7-Aug-2018

    Summary

    Official Symbol
    Gdf9provided by MGI
    Official Full Name
    growth differentiation factor 9provided by MGI
    Primary source
    MGI:MGI:95692
    See related
    Ensembl:ENSMUSG00000018238 Vega:OTTMUSG00000000055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gdf-9
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Female mice that are homozygous null for this gene are sterile with impaired folliculogenesis. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in ovary adult (RPKM 37.3) and testis adult (RPKM 3.0) See more
    Orthologs

    Genomic context

    See Gdf9 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.94 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (53430967..53437903)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53246788..53251405)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene predicted gene, 30585 Neighboring gene shroom family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystem
      Ovarian Infertility Genes
    • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
      Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
      Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of progesterone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    growth/differentiation factor 9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008110.2NP_032136.2  growth/differentiation factor 9 precursor

      See identical proteins and their annotated locations for NP_032136.2

      Status: REVIEWED

      Source sequence(s)
      AK136145, BC052667, CA559167
      Consensus CDS
      CCDS24679.1
      UniProtKB/Swiss-Prot
      Q07105
      UniProtKB/TrEMBL
      Q3UWR9, Q7TPZ4
      Related
      ENSMUSP00000018382.6, OTTMUSP00000000077, ENSMUST00000018382.6, OTTMUST00000000144
      Conserved Domains (1) summary
      pfam00019
      Location:338440
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      53430967..53437903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532221.3XP_006532284.1  growth/differentiation factor 9 isoform X2

      Conserved Domains (1) summary
      pfam00019
      Location:202304
      TGF_beta; Transforming growth factor beta like domain
    2. XM_006532220.3XP_006532283.1  growth/differentiation factor 9 isoform X1

      Conserved Domains (1) summary
      pfam00019
      Location:250352
      TGF_beta; Transforming growth factor beta like domain
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