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    Gdap2 ganglioside-induced differentiation-associated-protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14547, updated on 26-Sep-2022

    Summary

    Official Symbol
    Gdap2provided by MGI
    Official Full Name
    ganglioside-induced differentiation-associated-protein 2provided by MGI
    Primary source
    MGI:MGI:1338001
    See related
    Ensembl:ENSMUSG00000027865 AllianceGenome:MGI:1338001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Ertd801e
    Summary
    Acts upstream of or within response to retinoic acid. Is expressed in several structures, including brain; ganglia; liver; orbito-sphenoid; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.1), testis adult (RPKM 6.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gdap2 in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100069697..100114305)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100162381..100206989)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22505 Neighboring gene sperm associated antigen 17 Neighboring gene ribosomal protein L36, pseudogene 7 Neighboring gene WD repeat domain 3 Neighboring gene predicted gene, 25802 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ganglioside-induced differentiation-associated protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410111.1NP_001397040.1  ganglioside-induced differentiation-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    2. NM_001410112.1NP_001397041.1  ganglioside-induced differentiation-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    3. NM_010269.4NP_034399.1  ganglioside-induced differentiation-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_034399.1

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
      Consensus CDS
      CCDS17675.1
      UniProtKB/Swiss-Prot
      Q8C468, Q9DBL2
      Related
      ENSMUSP00000029459.4, ENSMUST00000029459.10
      Conserved Domains (2) summary
      cd02905
      Location:54193
      Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      pfam13716
      Location:350481
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RNA

    1. NR_104341.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    2. NR_176946.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    3. NR_176948.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    4. NR_176949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
    5. NR_176950.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100069697..100114305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501001.2XP_006501064.1  ganglioside-induced differentiation-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C468, Q9DBL2
      Conserved Domains (2) summary
      cd02905
      Location:54193
      Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      pfam13716
      Location:350481
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RNA

    1. XR_001783651.2 RNA Sequence