Format

Send to:

Choose Destination
    • Showing Current items.

    Gda guanine deaminase [ Mus musculus (house mouse) ]

    Gene ID: 14544, updated on 5-Sep-2021

    Summary

    Official Symbol
    Gdaprovided by MGI
    Official Full Name
    guanine deaminaseprovided by MGI
    Primary source
    MGI:MGI:95678
    See related
    Ensembl:ENSMUSG00000058624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAH; AU015411; AW047581
    Expression
    Broad expression in frontal lobe adult (RPKM 22.6), cortex adult (RPKM 19.1) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gda in Genome Data Viewer
    Location:
    19 B; 19 14.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21368671..21450025, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21391307..21472661, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (21465797..21547151, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene atherin-like Neighboring gene VISTA enhancer mm269 Neighboring gene zinc finger, AN1-type domain 5 Neighboring gene chromosome 19 C9orf57 homolog Neighboring gene predicted gene, 38486

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine deaminase
    Names
    guanase
    guanine aminase
    guanine aminohydrolase
    NP_034396.1
    XP_006526743.1
    XP_017173553.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010266.2NP_034396.1  guanine deaminase

      See identical proteins and their annotated locations for NP_034396.1

      Status: VALIDATED

      Source sequence(s)
      AC103947, AK041056, BY250819
      Consensus CDS
      CCDS29698.1
      UniProtKB/Swiss-Prot
      Q9R111
      UniProtKB/TrEMBL
      Q548F2
      Related
      ENSMUSP00000084882.4, ENSMUST00000087600.10
      Conserved Domains (1) summary
      cd01303
      Location:13444
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      21368671..21450025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526680.2XP_006526743.1  guanine deaminase isoform X1

      Related
      ENSMUSP00000157532.2, ENSMUST00000237823.2
      Conserved Domains (1) summary
      cd01303
      Location:2402
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...
    2. XM_017318064.3XP_017173553.1  guanine deaminase isoform X2

      UniProtKB/TrEMBL
      D3YU09
      Related
      ENSMUSP00000112758.2, ENSMUST00000121725.8
      Conserved Domains (1) summary
      cl00281
      Location:1370
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
    Support Center