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    Kat2a K(lysine) acetyltransferase 2A [ Mus musculus (house mouse) ]

    Gene ID: 14534, updated on 22-Aug-2021

    Summary

    Official Symbol
    Kat2aprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 2Aprovided by MGI
    Primary source
    MGI:MGI:1343101
    See related
    Ensembl:ENSMUSG00000020918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcn; Gcn5; Gcn5l2; mmGCN5; AW212720; PCAF-B/G; 1110051E14Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.5), ovary adult (RPKM 29.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kat2a in Genome Data Viewer
    Location:
    11 D; 11 63.53 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100595572..100604427, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100704746..100712485, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100566062..100573768, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DEXH (Asp-Glu-X-His) box polypeptide 58 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables H3 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity (H4-K12 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone glutaryltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in alpha-tubulin acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone H3-K14 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within histone H4-K12 acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone succinylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine glutarylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT2A
    Names
    GCN5 general control of amino acid synthesis-like 2
    PCAF-B/GCN5
    general control of amino acid synthesis 5-like 2
    general control of amino acid synthesis protein 5-like 2
    general control of amino acid synthesis, yeast homolog-like 2
    general control of amino acid synthesis-like 2
    histone acetyltransferase GCN5
    histone glutaryltransferase KAT2A
    histone succinyltransferase KAT2A
    lysine acetyltransferase 2A
    NP_001033099.1
    NP_064388.2
    XP_017169759.2
    XP_017169760.2
    XP_017169761.1
    XP_017169762.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038010.2NP_001033099.1  histone acetyltransferase KAT2A isoform b

      See identical proteins and their annotated locations for NP_001033099.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK155842, AL591469, AV014576
      Consensus CDS
      CCDS25432.1
      UniProtKB/TrEMBL
      Q6P3Z8
      Related
      ENSMUSP00000006973.6, ENSMUST00000006973.12
      Conserved Domains (4) summary
      cd05509
      Location:724823
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:484824
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:547619
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:81330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. NM_020004.5NP_064388.2  histone acetyltransferase KAT2A isoform a

      See identical proteins and their annotated locations for NP_064388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK155842, AK158079, AL591469, AV014576
      Consensus CDS
      CCDS25433.1
      UniProtKB/Swiss-Prot
      Q9JHD2
      UniProtKB/TrEMBL
      Q6P3Z8
      Related
      ENSMUSP00000099407.4, ENSMUST00000103118.4
      Conserved Domains (3) summary
      cd05509
      Location:725824
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:485825
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:84330
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

    RNA

    1. NR_166132.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591469
      Related
      ENSMUST00000153526.8
    2. NR_166133.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591469

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100595572..100604427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314271.3XP_017169760.2  histone acetyltransferase KAT2A isoform X2

      Conserved Domains (3) summary
      cd05509
      Location:801900
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:532901
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:129378
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. XM_017314270.3XP_017169759.2  histone acetyltransferase KAT2A isoform X1

      Conserved Domains (3) summary
      cd05509
      Location:802901
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:533902
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:129378
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    3. XM_017314273.3XP_017169762.1  histone acetyltransferase KAT2A isoform X4

      Conserved Domains (2) summary
      cd05509
      Location:397496
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:128497
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    4. XM_017314272.3XP_017169761.1  histone acetyltransferase KAT2A isoform X3

      Conserved Domains (2) summary
      cd05509
      Location:398497
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:129498
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
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