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    Nipsnap2 nipsnap homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 14467, updated on 2-Nov-2024

    Summary

    Official Symbol
    Nipsnap2provided by MGI
    Official Full Name
    nipsnap homolog 2provided by MGI
    Primary source
    MGI:MGI:1278343
    See related
    Ensembl:ENSMUSG00000029432 AllianceGenome:MGI:1278343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbas
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy and positive regulation of high voltage-gated calcium channel activity. Located in cytoplasm. Is expressed in olfactory cortex ventricular layer; rest of cerebellum ventricular layer; and telencephalon ventricular layer. Orthologous to human NIPSNAP2 (nipsnap homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in heart adult (RPKM 142.2), cerebellum adult (RPKM 27.2) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Nipsnap2 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129802080..129835391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129725016..129758327)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene septin 14 Neighboring gene STARR-seq mESC enhancer starr_14455 Neighboring gene STARR-positive B cell enhancer ABC_E11303 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130230774-130230883 Neighboring gene STARR-seq mESC enhancer starr_14458 Neighboring gene STARR-seq mESC enhancer starr_14459 Neighboring gene phosphoserine phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E854 Neighboring gene predicted gene, 23245 Neighboring gene chaperonin containing TCP1 subunit 6A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of high voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein NipSnap homolog 2
    Names
    glioblastoma amplified sequence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008095.5NP_032121.3  protein NipSnap homolog 2

      See identical proteins and their annotated locations for NP_032121.3

      Status: VALIDATED

      Source sequence(s)
      AC120413, AC186296
      Consensus CDS
      CCDS19698.1
      UniProtKB/TrEMBL
      Q3TD78, Q7TMG8
      Related
      ENSMUSP00000083211.4, ENSMUST00000086046.10
      Conserved Domains (1) summary
      pfam07978
      Location:182279
      NIPSNAP; NIPSNAP

    RNA

    1. NR_185194.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC120413, AC186296

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129802080..129835391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_377054.4 RNA Sequence

    2. XR_377052.4 RNA Sequence