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    Gata4 GATA binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 14463, updated on 19-Mar-2019

    Summary

    Official Symbol
    Gata4provided by MGI
    Official Full Name
    GATA binding protein 4provided by MGI
    Primary source
    MGI:MGI:95664
    See related
    Ensembl:ENSMUSG00000021944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gata-4
    Expression
    Biased expression in ovary adult (RPKM 86.2), stomach adult (RPKM 63.9) and 5 other tissues See more
    Orthologs

    Genomic context

    See Gata4 in Genome Data Viewer
    Location:
    14 D1; 14 33.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (63198914..63271715, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (63817752..63864097, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cathepsin B Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei like 2 (E. coli) Neighboring gene predicted gene 4151 Neighboring gene predicted gene, 36165 Neighboring gene predicted gene, 46458

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
    • Regulation of Cardiac Hypertrophy by miR-208, organism-specific biosystem (from WikiPathways)
      Regulation of Cardiac Hypertrophy by miR-208, organism-specific biosystemMicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hyp...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    NFAT protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sertoli cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum primum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial septum secundum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular canal development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    atrioventricular valve formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    atrioventricular valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    atrioventricular valve morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiac muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cardiac muscle hypertrophy in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac muscle tissue regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to follicle-stimulating hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to gonadotropin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diaphragm morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic heart tube anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung lobe formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    mitral valve formation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of connective tissue replacement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of oxidative stress-induced cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outflow tract morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cardioblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial growth factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transdifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    tricuspid valve formation TAS
    Traceable Author Statement
    more info
    PubMed 
    tube morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    ventricular cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor GATA-4
    Names
    GATA-binding factor 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310610.1NP_001297539.1  transcription factor GATA-4 isoform 1

      See identical proteins and their annotated locations for NP_001297539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090962, AK134639, BB044491
      Consensus CDS
      CCDS79331.1
      UniProtKB/TrEMBL
      E9PXW9, Q3UYJ1
      Related
      ENSMUSP00000066927.3, ENSMUST00000067417.9
      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
    2. NM_008092.4NP_032118.2  transcription factor GATA-4 isoform 2

      See identical proteins and their annotated locations for NP_032118.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the central coding region compared to variant 1. The encoded isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AC090962, AK134639, BB044491
      Consensus CDS
      CCDS49519.1
      UniProtKB/Swiss-Prot
      Q08369
      UniProtKB/TrEMBL
      Q3UYJ1
      Related
      ENSMUSP00000113891.1, ENSMUST00000118022.7
      Conserved Domains (3) summary
      smart00401
      Location:267314
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:269320
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      63198914..63271715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244956.2XP_011243258.1  transcription factor GATA-4 isoform X1

      See identical proteins and their annotated locations for XP_011243258.1

      UniProtKB/TrEMBL
      E9PXW9
      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
    2. XM_011244957.2XP_011243259.1  transcription factor GATA-4 isoform X1

      See identical proteins and their annotated locations for XP_011243259.1

      UniProtKB/TrEMBL
      E9PXW9
      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
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