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    Gabpb1 GA repeat binding protein, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14391, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gabpb1provided by MGI
    Official Full Name
    GA repeat binding protein, beta 1provided by MGI
    Primary source
    MGI:MGI:95611
    See related
    Ensembl:ENSMUSG00000027361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BABP; NRF2; E4TF1; GABPB; BABPB2; E4Tf1B; NRF2B1; NRF2B2; GABPB-1; GABPB-2; E4TF1-47; E4TF1-53; GABPB1-1; GABPB1-2
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.0), limb E14.5 (RPKM 4.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gabpb1 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126470827..126527184, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126628907..126684435, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (126454649..126501223, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 2 Neighboring gene histidine decarboxylase Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene RIKEN cDNA A630026N12 gene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    GA-binding protein subunit beta-1
    Names
    GA binding protein subunit beta1
    GABP subunit beta-1
    GABP subunit beta-2
    Gabp beta1
    NP_001258396.1
    NP_001258397.1
    NP_001258398.1
    NP_001258399.1
    NP_001258421.1
    NP_001342037.1
    NP_001342038.1
    NP_034379.1
    NP_997552.1
    XP_006498818.1
    XP_006498819.1
    XP_006498820.1
    XP_006498822.1
    XP_006498823.1
    XP_006498824.1
    XP_006498825.1
    XP_006498827.1
    XP_030103378.1
    XP_030103382.1
    XP_030103383.1
    XP_030103385.1
    XP_030103386.1
    XP_030103387.1
    XP_030103388.1
    XP_030103389.1
    XP_036014243.1
    XP_036014247.1
    XP_036014249.1
    XP_036014261.1
    XP_036014264.1
    XP_036014265.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271467.1NP_001258396.1  GA-binding protein subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_001258396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform (a).
      Source sequence(s)
      AK140222, AL844555, BB732506
      Consensus CDS
      CCDS16685.1
      UniProtKB/Swiss-Prot
      Q00420
      UniProtKB/TrEMBL
      Q3US22
      Related
      ENSMUSP00000099517.2, ENSMUST00000103227.8
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315369
      Oberon_cc; Coiled-coil region of Oberon
    2. NM_001271468.1NP_001258397.1  GA-binding protein subunit beta-1 isoform d

      See identical proteins and their annotated locations for NP_001258397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform d which has one additional amino acid compared to isoform a.
      Source sequence(s)
      AL844555
      Consensus CDS
      CCDS71137.1
      UniProtKB/Swiss-Prot
      Q00420
      Related
      ENSMUSP00000106055.3, ENSMUST00000110425.9
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316370
      Oberon_cc; Coiled-coil region of Oberon
    3. NM_001271469.1NP_001258398.1  GA-binding protein subunit beta-1 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks several alternate in-frame exons in the coding region compared to variant 1. The resulting protein (isoform f) uses the same start codon but is shorter than isoform a. PubMed ID: 15656975 suggests that this protein lacks a nuclear localization signal found in isoform a.
      Source sequence(s)
      AL844555
      Conserved Domains (4) summary
      cd00204
      Location:1092
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:3891
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      cl03075
      Location:81130
      GrpE; nucleotide exchange factor GrpE
    4. NM_001271470.1NP_001258399.1  GA-binding protein subunit beta-1 isoform e

      See identical proteins and their annotated locations for NP_001258399.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AI324106, AK139710, AL844555
      Consensus CDS
      CCDS71136.1
      UniProtKB/TrEMBL
      Q3UT69
      Related
      ENSMUSP00000037673.7, ENSMUST00000039978.13
      Conserved Domains (4) summary
      cd00204
      Location:34156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
    5. NM_001271492.1NP_001258421.1  GA-binding protein subunit beta-1 isoform c

      See identical proteins and their annotated locations for NP_001258421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK040722, AL844555
      Consensus CDS
      CCDS71135.1
      UniProtKB/Swiss-Prot
      Q00420
      Related
      ENSMUSP00000087177.5, ENSMUST00000089745.11
      Conserved Domains (4) summary
      cd00204
      Location:34156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
    6. NM_001355108.1NP_001342037.1  GA-binding protein subunit beta-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844555
      Conserved Domains (3) summary
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1092
      Ank_2; Ankyrin repeats (3 copies)
      cl03075
      Location:259306
      GrpE; nucleotide exchange factor GrpE
    7. NM_001355109.1NP_001342038.1  GA-binding protein subunit beta-1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL844555
      Conserved Domains (2) summary
      cd00204
      Location:34156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
    8. NM_010249.2NP_034379.1  GA-binding protein subunit beta-1 isoform b

      See identical proteins and their annotated locations for NP_034379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) (also known as Gabp-beta-2, GABBP2, Gabp-beta-1-2, GABPbeta1S) uses an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AI324106, AL844555, AW492609, CA552206, CF730595
      Consensus CDS
      CCDS16686.1
      UniProtKB/Swiss-Prot
      Q00420
      Related
      ENSMUSP00000099516.4, ENSMUST00000103226.10
      Conserved Domains (4) summary
      cd00204
      Location:34156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
    9. NM_207669.2NP_997552.1  GA-binding protein subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_997552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) (also known as Gabp-beta-1, GABBP1, Gabp-beta-1-1, GABPbeta1L) encodes isoform a. Both variants 1 and 4 encode the same isoform (a).
      Source sequence(s)
      AK140907, AL844555, BB732506
      Consensus CDS
      CCDS16685.1
      UniProtKB/Swiss-Prot
      Q00420
      UniProtKB/TrEMBL
      Q3US22
      Related
      ENSMUSP00000106054.3, ENSMUST00000110424.9
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315369
      Oberon_cc; Coiled-coil region of Oberon

    RNA

    1. NR_073183.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two internal exons and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL844555

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126470827..126527184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498760.5XP_006498823.1  GA-binding protein subunit beta-1 isoform X3

      See identical proteins and their annotated locations for XP_006498823.1

      UniProtKB/Swiss-Prot
      Q00420
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316370
      Oberon_cc; Coiled-coil region of Oberon
    2. XM_036158371.1XP_036014264.1  GA-binding protein subunit beta-1 isoform X15

      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_030247525.2XP_030103385.1  GA-binding protein subunit beta-1 isoform X8

      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
    4. XM_006498757.5XP_006498820.1  GA-binding protein subunit beta-1 isoform X3

      See identical proteins and their annotated locations for XP_006498820.1

      UniProtKB/Swiss-Prot
      Q00420
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316370
      Oberon_cc; Coiled-coil region of Oberon
    5. XM_030247518.2XP_030103378.1  GA-binding protein subunit beta-1 isoform X3

      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316370
      Oberon_cc; Coiled-coil region of Oberon
    6. XM_006498759.5XP_006498822.1  GA-binding protein subunit beta-1 isoform X3

      See identical proteins and their annotated locations for XP_006498822.1

      UniProtKB/Swiss-Prot
      Q00420
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:316370
      Oberon_cc; Coiled-coil region of Oberon
    7. XM_036158350.1XP_036014243.1  GA-binding protein subunit beta-1 isoform X6

      Conserved Domains (3) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
    8. XM_030247528.1XP_030103388.1  GA-binding protein subunit beta-1 isoform X13

      Conserved Domains (3) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
    9. XM_006498755.1XP_006498818.1  GA-binding protein subunit beta-1 isoform X1

      Conserved Domains (4) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:324378
      Oberon_cc; Coiled-coil region of Oberon
    10. XM_006498762.2XP_006498825.1  GA-binding protein subunit beta-1 isoform X5

      Conserved Domains (3) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
    11. XM_036158372.1XP_036014265.1  GA-binding protein subunit beta-1 isoform X16

      Conserved Domains (2) summary
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1092
      Ank_2; Ankyrin repeats (3 copies)
    12. XM_030247527.2XP_030103387.1  GA-binding protein subunit beta-1 isoform X11

      Conserved Domains (3) summary
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1092
      Ank_2; Ankyrin repeats (3 copies)
      cl03075
      Location:259306
      GrpE; nucleotide exchange factor GrpE
    13. XM_030247522.2XP_030103382.1  GA-binding protein subunit beta-1 isoform X4

      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315369
      Oberon_cc; Coiled-coil region of Oberon
    14. XM_006498761.5XP_006498824.1  GA-binding protein subunit beta-1 isoform X4

      See identical proteins and their annotated locations for XP_006498824.1

      UniProtKB/Swiss-Prot
      Q00420
      UniProtKB/TrEMBL
      Q3US22
      Conserved Domains (4) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:315369
      Oberon_cc; Coiled-coil region of Oberon
    15. XM_036158368.1XP_036014261.1  GA-binding protein subunit beta-1 isoform X14

      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
    16. XM_030247526.1XP_030103386.1  GA-binding protein subunit beta-1 isoform X11

      Conserved Domains (3) summary
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1092
      Ank_2; Ankyrin repeats (3 copies)
      cl03075
      Location:259306
      GrpE; nucleotide exchange factor GrpE
    17. XM_036158354.1XP_036014247.1  GA-binding protein subunit beta-1 isoform X9

      Conserved Domains (3) summary
      sd00045
      Location:1843
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:18100
      Ank_2; Ankyrin repeats (3 copies)
      pfam16312
      Location:259313
      Oberon_cc; Coiled-coil region of Oberon
    18. XM_006498756.2XP_006498819.1  GA-binding protein subunit beta-1 isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
      pfam16312
      Location:323377
      Oberon_cc; Coiled-coil region of Oberon
    19. XM_036158356.1XP_036014249.1  GA-binding protein subunit beta-1 isoform X10

      Conserved Domains (3) summary
      sd00045
      Location:1035
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1092
      Ank_2; Ankyrin repeats (3 copies)
      pfam16312
      Location:250304
      Oberon_cc; Coiled-coil region of Oberon
    20. XM_030247529.2XP_030103389.1  GA-binding protein subunit beta-1 isoform X14

      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
    21. XM_030247523.2XP_030103383.1  GA-binding protein subunit beta-1 isoform X7

      Conserved Domains (3) summary
      sd00045
      Location:3868
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:42133
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1058
      Ank_4; Ankyrin repeats (many copies)
    22. XM_006498764.5XP_006498827.1  GA-binding protein subunit beta-1 isoform X12

      Conserved Domains (3) summary
      sd00045
      Location:4676
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:50141
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1866
      Ank_4; Ankyrin repeats (many copies)
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