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    G6pdx glucose-6-phosphate dehydrogenase X-linked [ Mus musculus (house mouse) ]

    Gene ID: 14381, updated on 19-Jul-2021

    Summary

    Official Symbol
    G6pdxprovided by MGI
    Official Full Name
    glucose-6-phosphate dehydrogenase X-linkedprovided by MGI
    Primary source
    MGI:MGI:105979
    See related
    Ensembl:ENSMUSG00000031400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G28; G6p; Gpd; G28A; G6pd; Gpdx
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 89.0), genital fat pad adult (RPKM 75.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See G6pdx in Genome Data Viewer
    Location:
    X A7.3; X 38.0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73453089..73472486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74409483..74428880, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71654825..71674500, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene predicted gene, 54057 Neighboring gene CTAG2 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glucose-6-phosphate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within NADP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within NADP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in NADPH regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein glutathionylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pentose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within pentose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pentose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribose phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glucose-6-phosphate 1-dehydrogenase X
    NP_032088.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008062.3NP_032088.1  glucose-6-phosphate 1-dehydrogenase X

      See identical proteins and their annotated locations for NP_032088.1

      Status: VALIDATED

      Source sequence(s)
      AW489257, BC075663
      Consensus CDS
      CCDS30232.1
      UniProtKB/Swiss-Prot
      Q00612
      UniProtKB/TrEMBL
      Q790Y8
      Related
      ENSMUSP00000004327.5, ENSMUST00000004327.11
      Conserved Domains (3) summary
      TIGR00871
      Location:30506
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35209
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:212503
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73453089..73472486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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