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    Ganab alpha glucosidase 2 alpha neutral subunit [ Mus musculus (house mouse) ]

    Gene ID: 14376, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ganabprovided by MGI
    Official Full Name
    alpha glucosidase 2 alpha neutral subunitprovided by MGI
    Primary source
    MGI:MGI:1097667
    See related
    Ensembl:ENSMUSG00000071650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G2; Gl; G2an; GluII; AU042638; mKIAA0088
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 61.9), placenta adult (RPKM 49.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ganab in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8875421..8894106)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8898057..8916742)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8972601..8991156)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810009A15 gene Neighboring gene LBH domain containing 1 Neighboring gene integrator complex subunit 5 Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC144011, MGC144012

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alpha-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucan 1,3-alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glucan 1,3-alpha-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucan 1,3-alpha-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in N-glycan processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within N-glycan processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of glucosidase II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of glucosidase II complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of glucosidase II complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neutral alpha-glucosidase AB
    Names
    alpha-glucosidase 2
    carbohydrate processing enzyme of the endoplasmic reticulum
    glucosidase II alpha-subunit
    glucosidase II subunit alpha
    NP_001280550.1
    NP_032086.1
    XP_006526740.1
    XP_006526741.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293621.1NP_001280550.1  neutral alpha-glucosidase AB isoform 2 precursor

      See identical proteins and their annotated locations for NP_001280550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC129217, AK081915, BB002622, BC094437
      Consensus CDS
      CCDS89335.1
      UniProtKB/Swiss-Prot
      Q8BHN3
      Related
      ENSMUSP00000158122.2, ENSMUST00000235274.2
      Conserved Domains (3) summary
      cd06603
      Location:384851
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:242384
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:365810
      Glyco_hydro_31; Glycosyl hydrolases family 31
    2. NM_008060.2NP_032086.1  neutral alpha-glucosidase AB isoform 1

      See identical proteins and their annotated locations for NP_032086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC129217, AK030722, AK081915, BB002622, BC128069
      Consensus CDS
      CCDS29557.1
      UniProtKB/Swiss-Prot
      Q8BHN3
      UniProtKB/TrEMBL
      A1A4T2
      Related
      ENSMUSP00000093965.4, ENSMUST00000096246.5
      Conserved Domains (3) summary
      cd06603
      Location:406873
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:264406
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:387832
      Glyco_hydro_31; Glycosyl hydrolases family 31

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8875421..8894106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526677.2XP_006526740.1  neutral alpha-glucosidase AB isoform X1

      Conserved Domains (2) summary
      cd06603
      Location:309776
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:167309
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    2. XM_006526678.2XP_006526741.1  neutral alpha-glucosidase AB isoform X2

      Conserved Domains (2) summary
      cd06603
      Location:287754
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:145287
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
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