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    MUC15 mucin 15, cell surface associated [ Homo sapiens (human) ]

    Gene ID: 143662, updated on 17-Jun-2024

    Summary

    Official Symbol
    MUC15provided by HGNC
    Official Full Name
    mucin 15, cell surface associatedprovided by HGNC
    Primary source
    HGNC:HGNC:14956
    See related
    Ensembl:ENSG00000169550 MIM:608566; AllianceGenome:HGNC:14956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAS3; MUC-15; PASIII
    Summary
    Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MUC15 in Genome Data Viewer
    Location:
    11p14.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (26559032..26572263, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (26699699..26712907, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (26580579..26593810, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 3 Neighboring gene ANO3 antisense RNA 1 Neighboring gene uncharacterized LOC105376598 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26544561-26545120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:26545121-26545680 Neighboring gene uncharacterized LOC124902648 Neighboring gene uncharacterized LOC107987160

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common body mass index-associated variants confer risk of extreme obesity.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135091.2NP_001128563.1  mucin-15 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC036114, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS44557.1
      UniProtKB/TrEMBL
      A0A0A0MT67
      Related
      ENSP00000431983.1, ENST00000529533.6
      Conserved Domains (1) summary
      pfam15672
      Location:47361
      Mucin15; Cell-membrane associated Mucin15
    2. NM_001135092.2NP_001128564.1  mucin-15 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC036114, AJ507429, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS44556.1
      UniProtKB/TrEMBL
      A0A0A0MTD6, A0A3B3IU37
      Related
      ENSP00000431945.1, ENST00000527569.1
      Conserved Domains (1) summary
      pfam15672
      Location:47311
      Mucin15; Cell-membrane associated Mucin15
    3. NM_145650.4NP_663625.2  mucin-15 isoform b precursor

      See identical proteins and their annotated locations for NP_663625.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC036114, AK128337, AY358668, BU676338, DA842986
      Consensus CDS
      CCDS7859.1
      UniProtKB/Swiss-Prot
      B3KY00, E9PII6, F8W945, Q6UWS3, Q8IXI8, Q8N387, Q8WW41
      Related
      ENSP00000397339.2, ENST00000455601.6
      Conserved Domains (1) summary
      pfam15672
      Location:20334
      Mucin15; Cell-membrane associated Mucin15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      26559032..26572263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      26699699..26712907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)