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    CSE1L chromosome segregation 1 like [ Homo sapiens (human) ]

    Gene ID: 1434, updated on 17-Jun-2024

    Summary

    Official Symbol
    CSE1Lprovided by HGNC
    Official Full Name
    chromosome segregation 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:2431
    See related
    Ensembl:ENSG00000124207 MIM:601342; AllianceGenome:HGNC:2431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAS; CSE1; XPO2
    Summary
    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in testis (RPKM 57.6), esophagus (RPKM 21.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CSE1L in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (49046312..49096949)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (50815816..50866450)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (47662849..47713486)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18053 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47663207-47663847 Neighboring gene synaptosome associated protein 23 pseudogene 1 Neighboring gene CSE1L divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr20:47734294-47734451 Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:47797000-47797528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:47835541-47836266 Neighboring gene DEAD-box helicase 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates chromosome segregation 1-like (yeast) in HEK 293T cells PubMed
    integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies nuclear import-export proteins Exp2 and RanBP9 as IN-binding partners PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117283, MGC130036, MGC130037

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    exportin-2
    Names
    CSE1 chromosome segregation 1-like
    cellular apoptosis susceptibility protein
    chromosome segregation 1-like protein
    epididymis secretory sperm binding protein
    exp2
    importin-alpha re-exporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256135.2NP_001243064.1  exportin-2 isoform 2

      See identical proteins and their annotated locations for NP_001243064.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AI018123, AI973168, BC109314, DC402014, EF426455
      Consensus CDS
      CCDS58773.1
      UniProtKB/TrEMBL
      B4DM31
      Related
      ENSP00000379495.3, ENST00000396192.7
      Conserved Domains (3) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      pfam03378
      Location:471906
      CAS_CSE1; CAS/CSE protein, C-terminus
      cl27876
      Location:156469
      Cse1; Cse1
    2. NM_001316.4NP_001307.2  exportin-2 isoform 1

      See identical proteins and their annotated locations for NP_001307.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AI018123, AI973168, BC109314, DC402014
      Consensus CDS
      CCDS13412.1
      UniProtKB/Swiss-Prot
      A3RLL6, B2R5T4, E1P5Y0, F8W904, O75432, P55060, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0
      UniProtKB/TrEMBL
      A0A384NKW7
      Related
      ENSP00000262982.2, ENST00000262982.3
      Conserved Domains (3) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      pfam03378
      Location:527962
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam08506
      Location:156526
      Cse1
    3. NM_001362762.2NP_001349691.1  exportin-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL121903, AL133174
      Conserved Domains (3) summary
      smart00913
      Location:29102
      IBN_N; Importin-beta N-terminal domain
      pfam08506
      Location:156525
      Cse1; Cse1
      pfam03378
      Location:527942
      CAS_CSE1; CAS/CSE protein, C-terminus

    RNA

    1. NR_045796.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks 3 consecutive exons, and uses alternate splice sites at 2 other exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI018123, AI973168, AK300589, BC109314, DC402014

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      49046312..49096949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      50815816..50866450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177436.1: Suppressed sequence

      Description
      NM_177436.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.