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    Aktip AKT interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 14339, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aktipprovided by MGI
    Official Full Name
    AKT interacting proteinprovided by MGI
    Primary source
    MGI:MGI:3693832
    See related
    Ensembl:ENSMUSG00000031667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ft; Fif; Ft1; Fts; AL023020
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.7), bladder adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Aktip in Genome Data Viewer
    Location:
    8 C4; 8 44.25 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (91834267..91862122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91111781..91135494, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (93647398..93659395, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1483 Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene, 39221 Neighboring gene predicted gene, 22428 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    AKT-interacting protein
    Names
    fused toes protein
    thymoma viral proto-oncogene 1 interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302266.1NP_001289195.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289195.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000119277.3, ENSMUST00000125257.3
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    2. NM_001302267.1NP_001289196.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289196.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, CJ153808, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000112375.2, ENSMUST00000120213.9
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    3. NM_001302268.1NP_001289197.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289197.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, AK158704, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000105238.3, ENSMUST00000109609.9
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    4. NM_001302337.1NP_001289266.1  AKT-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001289266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122441, AK017861, AK158704, BC034861, BM899517
      Consensus CDS
      CCDS85582.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Related
      ENSMUSP00000113379.3, ENSMUST00000120426.9
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    5. NM_001358934.1NP_001345863.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    6. NM_001358935.1NP_001345864.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    7. NM_001358936.1NP_001345865.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    8. NM_001358937.1NP_001345866.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Consensus CDS
      CCDS22519.1
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    9. NM_001358938.1NP_001345867.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Consensus CDS
      CCDS22519.1
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    10. NM_010241.5NP_034371.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_034371.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4
      Related
      ENSMUSP00000113769.2, ENSMUST00000120349.8
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      91834267..91862122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530673.5XP_006530736.1  AKT-interacting protein isoform X5

      See identical proteins and their annotated locations for XP_006530736.1

      UniProtKB/TrEMBL
      D3Z632
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    2. XM_030243297.2XP_030099157.1  AKT-interacting protein isoform X6

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    3. XM_030243295.2XP_030099155.1  AKT-interacting protein isoform X5

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    4. XM_030243294.2XP_030099154.1  AKT-interacting protein isoform X5

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    5. XM_030243296.2XP_030099156.1  AKT-interacting protein isoform X5

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    6. XM_030243291.2XP_030099151.1  AKT-interacting protein isoform X3

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    7. XM_017312574.3XP_017168063.1  AKT-interacting protein isoform X4

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    8. XM_011248307.4XP_011246609.1  AKT-interacting protein isoform X3

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    9. XM_030243289.2XP_030099149.1  AKT-interacting protein isoform X2

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    10. XM_011248304.4XP_011246606.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246606.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    11. XM_030243293.2XP_030099153.1  AKT-interacting protein isoform X4

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    12. XM_011248303.4XP_011246605.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246605.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    13. XM_030243292.2XP_030099152.1  AKT-interacting protein isoform X4

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    14. XM_036153758.1XP_036009651.1  AKT-interacting protein isoform X4

      Conserved Domains (1) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    15. XM_011248306.4XP_011246608.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246608.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    16. XM_030243290.1XP_030099150.1  AKT-interacting protein isoform X2

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    17. XM_017312571.1XP_017168060.1  AKT-interacting protein isoform X1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
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