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    Aktip thymoma viral proto-oncogene 1 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 14339, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aktipprovided by MGI
    Official Full Name
    thymoma viral proto-oncogene 1 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:3693832
    See related
    Ensembl:ENSMUSG00000031667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ft; Fif; Ft1; Fts; AL023020
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.7), bladder adult (RPKM 7.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Aktip in Genome Data Viewer
    Location:
    8 C4; 8 44.25 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (91107639..91135494, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (93647398..93659395, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene, 39221 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    FHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with HOPS complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    AKT-interacting protein
    Names
    fused toes protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302266.1NP_001289195.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289195.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000119277.2, ENSMUST00000125257.2
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    2. NM_001302267.1NP_001289196.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289196.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, BC034861, CJ153808, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000112375.1, ENSMUST00000120213.8
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    3. NM_001302268.1NP_001289197.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001289197.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, AK158704, BC034861, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4, Q05BP5
      Related
      ENSMUSP00000105238.2, ENSMUST00000109609.8
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    4. NM_001302337.1NP_001289266.1  AKT-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001289266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122441, AK017861, AK158704, BC034861, BM899517
      Consensus CDS
      CCDS85582.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z632, Q05BP5
      Related
      ENSMUSP00000113379.2, ENSMUST00000120426.8
      Conserved Domains (2) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:79218
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    5. NM_001358934.1NP_001345863.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    6. NM_001358935.1NP_001345864.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    7. NM_001358936.1NP_001345865.1  AKT-interacting protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    8. NM_001358937.1NP_001345866.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    9. NM_001358938.1NP_001345867.1  AKT-interacting protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122441, Z67963
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    10. NM_010241.5NP_034371.1  AKT-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_034371.1

      Status: VALIDATED

      Source sequence(s)
      AC122441, AK146459, Z67963
      Consensus CDS
      CCDS22519.1
      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4
      Related
      ENSMUSP00000113769.1, ENSMUST00000120349.7
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      91107639..91135494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530673.3XP_006530736.1  AKT-interacting protein isoform X5

      See identical proteins and their annotated locations for XP_006530736.1

      UniProtKB/TrEMBL
      D3Z632
      Conserved Domains (2) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:79218
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    2. XM_011248307.2XP_011246609.1  AKT-interacting protein isoform X3

      Conserved Domains (2) summary
      smart00212
      Location:74217
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:74213
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    3. XM_017312574.1XP_017168063.1  AKT-interacting protein isoform X4

    4. XM_011248302.2XP_011246604.1  AKT-interacting protein isoform X1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    5. XM_006530669.3XP_006530732.1  AKT-interacting protein isoform X1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    6. XM_011248304.2XP_011246606.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246606.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    7. XM_011248303.2XP_011246605.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246605.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    8. XM_017312573.1XP_017168062.1  AKT-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    9. XM_011248306.2XP_011246608.1  AKT-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_011246608.1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    10. XM_017312572.1XP_017168061.1  AKT-interacting protein isoform X2

      UniProtKB/Swiss-Prot
      Q64362
      UniProtKB/TrEMBL
      D3Z2J4
      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    11. XM_011248305.2XP_011246607.1  AKT-interacting protein isoform X1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    12. XM_017312571.1XP_017168060.1  AKT-interacting protein isoform X1

      Conserved Domains (1) summary
      smart00212
      Location:79222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
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