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    Ftl1 ferritin light polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 14325, updated on 19-Jun-2024

    Summary

    Official Symbol
    Ftl1provided by MGI
    Official Full Name
    ferritin light polypeptide 1provided by MGI
    Primary source
    MGI:MGI:95589
    See related
    Ensembl:ENSMUSG00000050708 AllianceGenome:MGI:95589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftl; Ftl-1; L-ferritin
    Summary
    Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be located in autolysosome. Predicted to be part of intracellular ferritin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ciliary body; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 4436.7), adrenal adult (RPKM 2649.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Ftl1 in Genome Data Viewer
    Location:
    7 B3; 7 29.32 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45107368..45109310, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45457944..45459886, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 2 Neighboring gene luteinizing hormone beta Neighboring gene STARR-positive B cell enhancer ABC_E349 Neighboring gene glycogen synthase 1, muscle Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase Neighboring gene TUB like protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102130, MGC102131, MGC118079, MGC118080

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular sequestering of iron ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    part_of ferritin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ferritin light chain 1
    Names
    ferritin L subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010240.2NP_034370.2  ferritin light chain 1

      See identical proteins and their annotated locations for NP_034370.2

      Status: VALIDATED

      Source sequence(s)
      AK169159, BC081462, BY134899
      Consensus CDS
      CCDS39952.1
      UniProtKB/Swiss-Prot
      P29391, Q8WUQ8
      UniProtKB/TrEMBL
      Q3TJJ6, Q3UCL5, Q9CPX4
      Related
      ENSMUSP00000092002.5, ENSMUST00000094434.13
      Conserved Domains (1) summary
      cd00904
      Location:10177
      Ferritin; Ferritin iron storage proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45107368..45109310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)