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    Ftl1 ferritin light polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 14325, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ftl1provided by MGI
    Official Full Name
    ferritin light polypeptide 1provided by MGI
    Primary source
    MGI:MGI:95589
    See related
    Ensembl:ENSMUSG00000050708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftl; Ftl-1; L-ferritin
    Expression
    Ubiquitous expression in liver adult (RPKM 4436.7), adrenal adult (RPKM 2649.8) and 23 other tissues See more
    Orthologs

    Genomic context

    See Ftl1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (45457944..45459886, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52713314..52715256, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene luteinizing hormone beta Neighboring gene RuvB-like protein 2 Neighboring gene glycogen synthase 1, muscle Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase (dimeric) Neighboring gene tubby-like protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ferroptosis, organism-specific biosystem (from KEGG)
      Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Ferroptosis, conserved biosystem (from KEGG)
      Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Iron Homeostasis, organism-specific biosystem (from WikiPathways)
      Iron Homeostasis, organism-specific biosystemIron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.
    • Mineral absorption, organism-specific biosystem (from KEGG)
      Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Mineral absorption, conserved biosystem (from KEGG)
      Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102130, MGC102131, MGC118079, MGC118080

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT ferroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular sequestering of iron ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    autolysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autolysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ferritin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular ferritin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ferritin light chain 1
    Names
    ferritin L subunit 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010240.2NP_034370.2  ferritin light chain 1

      See identical proteins and their annotated locations for NP_034370.2

      Status: VALIDATED

      Source sequence(s)
      AK169159, BC081462, BY134899
      Consensus CDS
      CCDS39952.1
      UniProtKB/TrEMBL
      Q9CPX4
      Related
      ENSMUSP00000092002.4, ENSMUST00000094434.12
      Conserved Domains (2) summary
      cd00904
      Location:10177
      Ferritin; Ferritin iron storage proteins
      pfam00210
      Location:14155
      Ferritin; Ferritin-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      45457944..45459886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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