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    MAPK14 mitogen-activated protein kinase 14 [ Homo sapiens (human) ]

    Gene ID: 1432, updated on 7-Jul-2024

    Summary

    Official Symbol
    MAPK14provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 14provided by HGNC
    Primary source
    HGNC:HGNC:6876
    See related
    Ensembl:ENSG00000112062 MIM:600289; AllianceGenome:HGNC:6876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK14 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36027808..36124214)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35848088..35944528)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35995585..36079013)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC105375035 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:35960877-35961390 Neighboring gene uncharacterized LOC105375034 Neighboring gene divergent-paired related homeobox pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35991863-35992364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35992365-35992864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17104 Neighboring gene Sharpr-MPRA regulatory region 2026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17105 Neighboring gene NUDT5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36098441-36099044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36106471-36106971 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene BRPF3 antisense RNA 1 Neighboring gene MPRA-validated peak5782 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene bromodomain and PHD finger containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation PubMed
    env HIV-1 Env (gp120) binds to CD209 (DC-SIGN), which activates NFKB1 (NF-kB), MAPK1 (ERK1/2), and MAPK14 (p38) PubMed
    env HIV-1 gp120-induced release of IL-6 is regulated by p38 MAPK, IkappaBalpha, and p65 NF-kappaB activation in primary human monocyte-derived dendritic cells PubMed
    env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed
    env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
    env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
    env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env HIV-1 gp120-mediated enhancement of potassium voltage-gated channel KV1.3 protein is required for microglia neurotoxicity through the p38 MAPK signaling pathway PubMed
    env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    env Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves p38 MAPK signaling pathway PubMed
    env HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway PubMed
    env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
    env HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1 PubMed
    env Treatment of human hepatic stellate cells with gp120 significantly increases secretion and gene expression of CCL2, metalloprotease-1 and interleukin-6. Gp120 also induces activation of Akt, NF-kappaB, and p38(MAPK) PubMed
    env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
    env HIV-1 gp120-induced neuronal cell death involves p38 mitogen-activated protein kinase; both HIV-1 coreceptors, CCR5 and CXCR4, can mediate HIV-1 gp120-induced neurotoxicity PubMed
    env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env HIV-1 gp120-induced increases in caspase-3 activity, neurite losses and neuronal death are prevented by p38 MAPK, but not c-jun-N-terminal kinase PubMed
    env STAT1 associates with p38 MAP kinase in a time-dependent manner after HIV-1 gp120/HCV E2 costimulation in human hepatocytes PubMed
    env HCV-E2 and HIV-1 gp120 act collaboratively to trigger a specific set of downstream signaling pathways that include activation of p38 mitogen-activated protein (MAP) kinase and the tyrosine phosphatase, SHP2, in hepatocytes PubMed
    env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not PubMed
    env Morphine potentiates HIV-1 gp120-induced neuronal apoptosis, which involves activation of the p38 MAPK cellular signaling pathway PubMed
    Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    Nef nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
    nef HIV-1 Nef induces phosphorylation of p38 MAPK in M2-type macrophages PubMed
    nef Knockdown of p38 MAPK alpha or delta by siRNA shows significant reduction of CCL5 levels, suggesting that p38 MAPK alpha and delta proteins are involved in Nef-mediated upregulation of CCL5 PubMed
    nef HIV-1 Nef-induced programmed death 1 (PD-1) upregulation requires its proline-rich motif and the activation of the downstream kinase p38 PubMed
    nef Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter PubMed
    nef HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members PubMed
    Tat tat HIV-1 Tat protein activates RELA (p65), MAP kinases ERK1/2 and p38, and PKC-bII in a TLR4-dependent manner in human monocytes PubMed
    tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
    tat HIV-1 Tat induces phosphorylation of MAPK14 (p38) in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
    tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
    tat HIV-1 Tat-mediated upregulation of ICAM-1 expression involves MEK1/2, JNK, and p38 MAPK proteins and downstream IKK2/NF-kappaB signaling pathways PubMed
    tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
    tat Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 PubMed
    tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
    tat Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes PubMed
    tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed
    Vpr vpr HIV-1 Vpr-induced retrotransposition of long interspersed element-1 depends on an AhR-MAPK/p38-C/EBP-beta cascade via the LQQLL motif of Vpr PubMed
    vpr HIV-1 Vpr induces IL-6 production via activation of MAPK p38 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NFAT protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase p38 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to UV-B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipoteichoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to antigenic stimulus TAS
    Traceable Author Statement
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in p38MAPK cascade TAS
    Traceable Author Statement
    more info
     
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet activation TAS
    Traceable Author Statement
    more info
     
    NOT involved_in positive regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of myoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic membrane adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muramyl dipeptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress-activated protein kinase signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 14
    Names
    CSAID-binding protein
    MAP kinase 14
    MAP kinase Mxi2
    MAP kinase p38 alpha
    MAX-interacting protein 2
    cytokine suppressive anti-inflammatory drug binding protein
    mitogen-activated protein kinase p38 alpha
    p38 MAP kinase
    p38 mitogen activated protein kinase
    p38alpha Exip
    stress-activated protein kinase 2A
    NP_001306.1
    NP_620581.1
    NP_620582.1
    NP_620583.1
    XP_006715061.1
    XP_011512612.2
    XP_016865788.1
    XP_016865789.1
    XP_047274188.1
    XP_047274189.1
    XP_047274190.1
    XP_047274191.1
    XP_047274192.1
    XP_047274193.1
    XP_054210307.1
    XP_054210308.1
    XP_054210309.1
    XP_054210310.1
    XP_054210311.1
    XP_054210312.1
    XP_054210313.1
    XP_054210314.1
    XP_054210315.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001315.3NP_001306.1  mitogen-activated protein kinase 14 isoform 1

      See identical proteins and their annotated locations for NP_001306.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      L35263, Z95152
      Consensus CDS
      CCDS4815.1
      UniProtKB/TrEMBL
      L7RSM2
      Related
      ENSP00000229795.3, ENST00000229795.8
      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    2. NM_139012.3NP_620581.1  mitogen-activated protein kinase 14 isoform 2

      See identical proteins and their annotated locations for NP_620581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1.
      Source sequence(s)
      AF100544, DA438432, Z95152
      Consensus CDS
      CCDS4816.1
      UniProtKB/Swiss-Prot
      A6ZJ92, A8K6P4, B0LPH0, B5TY32, O60776, Q13083, Q14084, Q16539, Q8TDX0
      Related
      ENSP00000229794.4, ENST00000229794.9
      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
    3. NM_139013.3NP_620582.1  mitogen-activated protein kinase 14 isoform 3

      See identical proteins and their annotated locations for NP_620582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal segment, and a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      DA438432, U19775, Z95152
      UniProtKB/Swiss-Prot
      Q16539
      Conserved Domains (2) summary
      smart00220
      Location:24262
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:6281
      PKc_like; Protein Kinases, catalytic domain
    4. NM_139014.3NP_620583.1  mitogen-activated protein kinase 14 isoform 4

      See identical proteins and their annotated locations for NP_620583.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1.
      Source sequence(s)
      AB074150, DA438432, Z95152
      Consensus CDS
      CCDS4817.1
      UniProtKB/Swiss-Prot
      Q16539
      Related
      ENSP00000308669.4, ENST00000310795.8
      Conserved Domains (1) summary
      cl21453
      Location:6257
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36027808..36124214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010299.3XP_016865788.1  mitogen-activated protein kinase 14 isoform X6

    2. XM_017010300.3XP_016865789.1  mitogen-activated protein kinase 14 isoform X5

    3. XM_047418233.1XP_047274189.1  mitogen-activated protein kinase 14 isoform X3

    4. XM_047418235.1XP_047274191.1  mitogen-activated protein kinase 14 isoform X9

    5. XM_047418234.1XP_047274190.1  mitogen-activated protein kinase 14 isoform X4

    6. XM_011514310.4XP_011512612.2  mitogen-activated protein kinase 14 isoform X1

    7. XM_047418232.1XP_047274188.1  mitogen-activated protein kinase 14 isoform X2

    8. XM_047418236.1XP_047274192.1  mitogen-activated protein kinase 14 isoform X7

    9. XM_047418237.1XP_047274193.1  mitogen-activated protein kinase 14 isoform X8

      UniProtKB/TrEMBL
      B4E0K5
    10. XM_006714998.4XP_006715061.1  mitogen-activated protein kinase 14 isoform X8

      See identical proteins and their annotated locations for XP_006715061.1

      UniProtKB/TrEMBL
      B4E0K5
      Related
      ENSP00000419837.1, ENST00000468133.5
      Conserved Domains (1) summary
      cl21453
      Location:1273
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_007059209.1 RNA Sequence

    2. XR_007059210.1 RNA Sequence

    3. XR_007059211.1 RNA Sequence

    4. XR_926065.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      35848088..35944528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354332.1XP_054210307.1  mitogen-activated protein kinase 14 isoform X1

    2. XM_054354333.1XP_054210308.1  mitogen-activated protein kinase 14 isoform X2

    3. XM_054354337.1XP_054210312.1  mitogen-activated protein kinase 14 isoform X6

    4. XM_054354336.1XP_054210311.1  mitogen-activated protein kinase 14 isoform X5

    5. XM_054354334.1XP_054210309.1  mitogen-activated protein kinase 14 isoform X3

    6. XM_054354335.1XP_054210310.1  mitogen-activated protein kinase 14 isoform X4

    7. XM_054354338.1XP_054210313.1  mitogen-activated protein kinase 14 isoform X7

    8. XM_054354340.1XP_054210315.1  mitogen-activated protein kinase 14 isoform X10

    9. XM_054354339.1XP_054210314.1  mitogen-activated protein kinase 14 isoform X8

      UniProtKB/TrEMBL
      B4E0K5

    RNA

    1. XR_008487260.1 RNA Sequence

    2. XR_008487261.1 RNA Sequence

    3. XR_008487258.1 RNA Sequence

    4. XR_008487259.1 RNA Sequence