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    Fmr1 FMRP translational regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 14265, updated on 14-Sep-2021

    Summary

    Official Symbol
    Fmr1provided by MGI
    Official Full Name
    FMRP translational regulator 1provided by MGI
    Primary source
    MGI:MGI:95564
    See related
    Ensembl:ENSMUSG00000000838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FM; FMRP; Fmr-; Fmr-1
    Expression
    Broad expression in CNS E11.5 (RPKM 14.2), limb E14.5 (RPKM 13.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fmr1 in Genome Data Viewer
    Location:
    X A7.1; X 34.83 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (67722142..67761569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (68678536..68717963)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (65931730..65971138)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene S-adenosylhomocysteine hydrolase pseudogene Neighboring gene FMRP translational regulator 1, opposite strand Neighboring gene Fmr1 neighbor Neighboring gene serine/threonine/tyrosine interacting protein, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA strand annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hydroxyurea IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation by host of viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of histone phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular transport of viral material ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of modification of synaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation at postsynapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation at presynapse, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interleukin-17 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SMN complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendritic filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendritic spine neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine neck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mRNA cap binding complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of messenger ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spine apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synaptic functional regulator FMR1
    Names
    fragile X mental retardation 1
    fragile X mental retardation protein 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290424.1NP_001277353.1  synaptic functional regulator FMR1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF461114, AK053829, BC079671
      Consensus CDS
      CCDS72385.1
      UniProtKB/TrEMBL
      E9QAT0, Q547R0, Q6AXB7, Q8BPK8
      Related
      ENSMUSP00000110301.2, ENSMUST00000114653.2
      Conserved Domains (5) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      cd00105
      Location:286325
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:419546
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:524589
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
    2. NM_001374719.1NP_001361648.1  synaptic functional regulator FMR1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC055766
      Consensus CDS
      CCDS90720.1
      Related
      ENSMUSP00000110305.3, ENSMUST00000114657.9
      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285332
      KH_1; KH domain
      pfam12235
      Location:398501
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:528593
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam17904
      Location:123207
      KH_9; FMRP KH0 domain
      pfam18336
      Location:452
      Tudor_FRX1; Fragile X mental retardation Tudor domain
    3. NM_008031.3NP_032057.2  synaptic functional regulator FMR1 isoform 1

      See identical proteins and their annotated locations for NP_032057.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK053829, BC079671
      Consensus CDS
      CCDS30171.1
      UniProtKB/TrEMBL
      Q6AXB7, Q8BPK8
      Related
      ENSMUSP00000085906.6, ENSMUST00000088546.12
      Conserved Domains (5) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:283323
      KH_1; KH domain
      pfam05641
      Location:63120
      Agenet; Agenet domain
      pfam12235
      Location:419571
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:549614
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      67722142..67761569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527813.2XP_006527876.1  synaptic functional regulator FMR1 isoform X2

      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285332
      KH_1; KH domain
      pfam12235
      Location:398489
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:516581
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam17904
      Location:123207
      KH_9; FMRP KH0 domain
      pfam18336
      Location:452
      Tudor_FRX1; Fragile X mental retardation Tudor domain
    2. XM_006527814.2XP_006527877.1  synaptic functional regulator FMR1 isoform X3

      Related
      ENSMUSP00000110302.2, ENSMUST00000114654.8
      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285332
      KH_1; KH domain
      pfam12235
      Location:398470
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:503568
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam17904
      Location:123207
      KH_9; FMRP KH0 domain
      pfam18336
      Location:452
      Tudor_FRX1; Fragile X mental retardation Tudor domain
    3. XM_006527810.3XP_006527873.1  synaptic functional regulator FMR1 isoform X1

      Conserved Domains (6) summary
      smart00322
      Location:221280
      KH; K homology RNA-binding domain
      pfam00013
      Location:285332
      KH_1; KH domain
      pfam12235
      Location:419510
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16098
      Location:537602
      FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2
      pfam17904
      Location:123207
      KH_9; FMRP KH0 domain
      pfam18336
      Location:452
      Tudor_FRX1; Fragile X mental retardation Tudor domain

    RNA

    1. XR_001782738.3 RNA Sequence

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