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    Flot2 flotillin 2 [ Mus musculus (house mouse) ]

    Gene ID: 14252, updated on 5-Sep-2021

    Summary

    Official Symbol
    Flot2provided by MGI
    Official Full Name
    flotillin 2provided by MGI
    Primary source
    MGI:MGI:103309
    See related
    Ensembl:ENSMUSG00000061981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E; Esa; reggie; AI573412; reggie-2
    Expression
    Ubiquitous expression in adrenal adult (RPKM 67.2), mammary gland adult (RPKM 55.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Flot2 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77928757..77951260)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78037931..78060434)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77851443..77873934)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 12 Neighboring gene predicted gene, 51908 Neighboring gene dehydrogenase/reductase (SDR family) member 13, opposite strand Neighboring gene dehydrogenase/reductase (SDR family) member 13 Neighboring gene uncharacterized LOC118567921 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anterograde dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of T cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of flotillin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of flotillin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of flotillin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    flotillin-2
    Names
    epidermal surface antigen
    membrane component chromosome 17 surface marker 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040403.2NP_001035493.1  flotillin-2 isoform 1

      See identical proteins and their annotated locations for NP_001035493.1

      Status: VALIDATED

      Source sequence(s)
      AL669840, BC070423, BY204171, CD774654
      Consensus CDS
      CCDS36237.1
      UniProtKB/Swiss-Prot
      Q60634
      Related
      ENSMUSP00000072136.6, ENSMUST00000072289.12
      Conserved Domains (2) summary
      COG2268
      Location:6417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. NM_001284227.2NP_001271156.1  flotillin-2 isoform 3

      See identical proteins and their annotated locations for NP_001271156.1

      Status: VALIDATED

      Source sequence(s)
      AK149530, AL669840, BC070423, BY195482, CD774654
      UniProtKB/Swiss-Prot
      Q60634
      UniProtKB/TrEMBL
      Q3UEG9
      Conserved Domains (3) summary
      smart00244
      Location:115297
      PHB; prohibitin homologues
      cd03399
      Location:72206
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
      pfam15975
      Location:341415
      Flot; Flotillin
    3. NM_001284228.3NP_001271157.1  flotillin-2 isoform 2

      See identical proteins and their annotated locations for NP_001271157.1

      Status: VALIDATED

      Source sequence(s)
      AL669840, BC070423, CD774654, U07890
      Consensus CDS
      CCDS25088.1
      UniProtKB/Swiss-Prot
      Q60634
      Related
      ENSMUST00000136353.2
      Conserved Domains (2) summary
      COG2268
      Location:1368
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1129
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    4. NM_001362625.1NP_001349554.1  flotillin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL669840, CD774654
      Consensus CDS
      CCDS88200.1
      Related
      ENSMUSP00000073342.7, ENSMUST00000073660.7
      Conserved Domains (2) summary
      COG2268
      Location:6417
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:34178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    5. NM_001362626.1NP_001349555.1  flotillin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669840, CD774654
      Consensus CDS
      CCDS25088.1
      Conserved Domains (2) summary
      COG2268
      Location:1368
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1129
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    6. NM_001362627.1NP_001349556.1  flotillin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669840, CD774654
      Conserved Domains (2) summary
      COG2268
      Location:8340
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1101
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    7. NM_008028.4NP_032054.1  flotillin-2 isoform 2

      See identical proteins and their annotated locations for NP_032054.1

      Status: VALIDATED

      Source sequence(s)
      AK149530, AL669840, BC070423, BY195482, CD774654
      Consensus CDS
      CCDS25088.1
      UniProtKB/Swiss-Prot
      Q60634
      Related
      ENSMUSP00000098347.3, ENSMUST00000100784.9
      Conserved Domains (2) summary
      COG2268
      Location:1368
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1129
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77928757..77951260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245558.1XP_030101418.1  flotillin-2 isoform X3

      Conserved Domains (2) summary
      COG2268
      Location:8340
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1101
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    2. XM_030245557.2XP_030101417.1  flotillin-2 isoform X1

      Conserved Domains (2) summary
      COG2268
      Location:7380
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:7141
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    3. XM_036156327.1XP_036012220.1  flotillin-2 isoform X2

      Conserved Domains (2) summary
      COG2268
      Location:1368
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:1129
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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