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    Fkbp5 FK506 binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 14229, updated on 22-Aug-2021

    Summary

    Official Symbol
    Fkbp5provided by MGI
    Official Full Name
    FK506 binding protein 5provided by MGI
    Primary source
    MGI:MGI:104670
    See related
    Ensembl:ENSMUSG00000024222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dit; Dit1; FKBP-5; FKBP51; D17Ertd592; D17Ertd592e
    Expression
    Broad expression in ovary adult (RPKM 58.3), genital fat pad adult (RPKM 40.8) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Fkbp5 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28617727..28705123, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28398753..28486149, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28536040..28578001, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TEA domain family member 3 Neighboring gene tubby like protein 1 Neighboring gene predicted gene, 22146 Neighboring gene RIKEN cDNA E230001N04 gene Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FK506 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP5
    Names
    51 kDa FK506-binding protein
    51 kDa FKBP
    PPIase FKBP5
    rotamase
    NP_034350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010220.4NP_034350.1  peptidyl-prolyl cis-trans isomerase FKBP5

      See identical proteins and their annotated locations for NP_034350.1

      Status: VALIDATED

      Source sequence(s)
      AC154912, BU613862, BY740772, CF949740
      Consensus CDS
      CCDS37528.1
      UniProtKB/Swiss-Prot
      Q64378
      UniProtKB/TrEMBL
      Q4FJN2
      Related
      ENSMUSP00000078382.4, ENSMUST00000079413.11
      Conserved Domains (5) summary
      smart00028
      Location:319350
      TPR; Tetratricopeptide repeats
      sd00006
      Location:319345
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:44135
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:352384
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:319382
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28617727..28705123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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