U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Fkbp5 FK506 binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 14229, updated on 18-Sep-2024

    Summary

    Official Symbol
    Fkbp5provided by MGI
    Official Full Name
    FK506 binding protein 5provided by MGI
    Primary source
    MGI:MGI:104670
    See related
    Ensembl:ENSMUSG00000024222 AllianceGenome:MGI:104670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dit1; FKBP-5; FKBP51; D17Ertd592e
    Summary
    Predicted to enable heat shock protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Acts upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; integumental system; and reproductive system. Human ortholog(s) of this gene implicated in major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 58.3), genital fat pad adult (RPKM 40.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fkbp5 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28617727..28705123, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28398753..28486149, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TEA domain family member 3 Neighboring gene STARR-seq mESC enhancer starr_42209 Neighboring gene TUB like protein 1 Neighboring gene STARR-seq mESC enhancer starr_42210 Neighboring gene predicted gene, 22146 Neighboring gene RIKEN cDNA E230001N04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10942 Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to alcohol IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP5
    Names
    51 kDa FK506-binding protein
    51 kDa FKBP
    PPIase FKBP5
    rotamase
    NP_034350.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010220.4NP_034350.1  peptidyl-prolyl cis-trans isomerase FKBP5

      See identical proteins and their annotated locations for NP_034350.1

      Status: VALIDATED

      Source sequence(s)
      AC154912, BU613862, BY740772, CF949740
      Consensus CDS
      CCDS37528.1
      UniProtKB/Swiss-Prot
      Q64378
      UniProtKB/TrEMBL
      Q3TX72, Q4FJN2
      Related
      ENSMUSP00000078382.4, ENSMUST00000079413.11
      Conserved Domains (5) summary
      smart00028
      Location:319350
      TPR; Tetratricopeptide repeats
      sd00006
      Location:319345
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:44135
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:352384
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:319382
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28617727..28705123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)