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    Fkbp4 FK506 binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 14228, updated on 28-Jun-2021

    Summary

    Official Symbol
    Fkbp4provided by MGI
    Official Full Name
    FK506 binding protein 4provided by MGI
    Primary source
    MGI:MGI:95543
    See related
    Ensembl:ENSMUSG00000030357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p59; FKBP5; FKBP-4; FKBP-5; FKBP52; FKPB52; FKBP-52; AL022792; AW208983
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 152.7), testis adult (RPKM 150.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fkbp4 in Genome Data Viewer
    Location:
    6; 6 F3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128407066..128415619, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128430103..128438656, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128380125..128388649, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1 Neighboring gene peptidyl prolyl isomerase H pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables FK506 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables copper-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucocorticoid receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP4
    Names
    52 kDa FK506-binding protein
    52 kDa FKBP
    59 kDa immunophilin
    FKBP59
    HBI
    HSP-binding immunophilin
    PPIase FKBP4
    immunophilin FKBP52
    rotamase
    NP_034349.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010219.4NP_034349.1  peptidyl-prolyl cis-trans isomerase FKBP4

      See identical proteins and their annotated locations for NP_034349.1

      Status: VALIDATED

      Source sequence(s)
      AK083912, BY280598, X17069
      Consensus CDS
      CCDS20573.1
      UniProtKB/Swiss-Prot
      P30416
      Related
      ENSMUSP00000032508.5, ENSMUST00000032508.11
      Conserved Domains (4) summary
      sd00006
      Location:274301
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:43134
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:321352
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:322384
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128407066..128415619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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