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    Fkbp4 FK506 binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 14228, updated on 12-Mar-2019

    Summary

    Official Symbol
    Fkbp4provided by MGI
    Official Full Name
    FK506 binding protein 4provided by MGI
    Primary source
    MGI:MGI:95543
    See related
    Ensembl:ENSMUSG00000030357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p59; FKBP-4; FKBP52; FKPB52; FKBP-52; AL022792; AW208983
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 152.7), testis adult (RPKM 150.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fkbp4 in Genome Data Viewer
    Location:
    6; 6 F3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (128430107..128438631, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128380125..128388649, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein pseudogene Neighboring gene peptidyl prolyl isomerase H pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    FK506 binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male sex differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid hormone receptor complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP4
    Names
    52 kDa FK506-binding protein
    52 kDa FKBP
    59 kDa immunophilin
    FKBP59
    HBI
    HSP-binding immunophilin
    PPIase FKBP4
    immunophilin FKBP52
    rotamase
    NP_034349.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010219.4NP_034349.1  peptidyl-prolyl cis-trans isomerase FKBP4

      See identical proteins and their annotated locations for NP_034349.1

      Status: VALIDATED

      Source sequence(s)
      AK083912, BY280598, X17069
      Consensus CDS
      CCDS20573.1
      UniProtKB/Swiss-Prot
      P30416
      Related
      ENSMUSP00000032508.4, ENSMUST00000032508.10
      Conserved Domains (4) summary
      sd00006
      Location:274301
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:43134
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:321352
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:322384
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      128430107..128438631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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